Cell type atlas - HNRNPA1 - The Human Protein Atlas

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HNRNPA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HNRNPA1
Gene descriptionⁱ Full gene name according to HGNC.	Heterogeneous nuclear ribonucleoprotein A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	283 NX
Lung	283 NX

Alveolar cells type 2	417 NX
Lung	417 NX

B-cells	979 NX
Liver	1083 NX
Colon	897 NX
Kidney	838 NX

Basal glandular cells	866 NX
Prostate	866 NX

Basal keratinocytes	1258 NX
Skin	1258 NX

Bipolar cells	240 NX
Eye	240 NX

Cardiomyocytes	145 NX
Heart muscle	145 NX

Cholangiocytes	512 NX
Liver	512 NX

Ciliated cells	277 NX
Lung	277 NX

Club cells	532 NX
Lung	532 NX

Collecting duct cells	279 NX
Kidney	279 NX

Cone photoreceptor cells	88 NX
Eye	88 NX

Cytotrophoblasts	1847 NX
Placenta	1847 NX

Distal tubular cells	627 NX
Kidney	627 NX

Ductal cells	1015 NX
Pancreas	1015 NX

Early spermatids	132 NX
Testis	132 NX

Endothelial cells	691 NX
Skin	1049 NX
Placenta	977 NX
Testis	856 NX
Pancreas	713 NX
Prostate	691 NX
Liver	456 NX
Lung	318 NX
Eye	295 NX
Heart muscle	116 NX

Enterocytes	447 NX
Small intestine	580 NX
Colon	446 NX
Rectum	242 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	1835 NX
Pancreas	1835 NX

Extravillous trophoblasts	2354 NX
Placenta	2354 NX

Fibroblasts	906 NX
Placenta	1152 NX
Skin	819 NX
Lung	663 NX
Prostate	609 NX
Heart muscle	118 NX

Glandular cells	556 NX
Prostate	556 NX

Granulocytes	513 NX
Lung	540 NX
Colon	487 NX

Hepatocytes	175 NX
Liver	175 NX

Hofbauer cells	878 NX
Placenta	878 NX

Horizontal cells	103 NX
Eye	103 NX

Intestinal endocrine cells	792 NX
Rectum	880 NX
Colon	703 NX

Ito cells	392 NX
Liver	392 NX

Kupffer cells	666 NX
Liver	666 NX

Late spermatids	96 NX
Testis	95 NX

Leydig cells	973 NX
Testis	973 NX

Macrophages	726 NX
Testis	914 NX
Skin	875 NX
Prostate	758 NX
Kidney	694 NX
Pancreas	625 NX
Lung	414 NX

Melanocytes	559 NX
Skin	559 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1334 NX
Pancreas	1334 NX

Mucus-secreting cells	1093 NX
Rectum	1225 NX
Colon	962 NX
Small intestine	859 NX

Muller glia cells	204 NX
Eye	204 NX

Pancreatic endocrine cells	1143 NX
Pancreas	1143 NX

Paneth cells	523 NX
Rectum	1095 NX
Small intestine	523 NX
Colon	371 NX

Peritubular cells	697 NX
Testis	697 NX

Proximal tubular cells	587 NX
Kidney	587 NX

Rod photoreceptor cells	150 NX
Eye	150 NX

Sertoli cells	446 NX
Testis	446 NX

Smooth muscle cells	925 NX
Skin	1273 NX
Prostate	925 NX
Pancreas	863 NX
Heart muscle	107 NX

Spermatocytes	197 NX
Testis	197 NX

Spermatogonia	318 NX
Testis	318 NX

Suprabasal keratinocytes	1103 NX
Skin	1103 NX

Syncytiotrophoblasts	1822 NX
Placenta	1822 NX

T-cells	976 NX
Skin	1215 NX
Liver	1212 NX
Kidney	976 NX
Colon	820 NX
Prostate	593 NX
Lung	495 NX

Undifferentiated cells	1320 NX
Small intestine	1841 NX
Rectum	1320 NX
Colon	971 NX

Urothelial cells	751 NX
Prostate	751 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.