Cell type atlas - PRRG4 - The Human Protein Atlas

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PRRG4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRRG4
Gene descriptionⁱ Full gene name according to HGNC.	Proline rich and Gla domain 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Suprabasal keratinocytes, Glandular cells, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HaCaT, hTCEpi, SK-BR-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Suprabasal keratinocytes, Glandular cells, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	3 NX
Colon	11 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	110 NX
Skin	110 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	29 NX
Lung	29 NX

Club cells	19 NX
Lung	19 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	20 NX
Placenta	20 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	26 NX
Pancreas	26 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	8 NX
Skin	19 NX
Prostate	17 NX
Pancreas	14 NX
Testis	10 NX
Liver	7 NX
Lung	6 NX
Heart muscle	6 NX
Eye	3 NX
Placenta	2 NX

Enterocytes	42 NX
Colon	50 NX
Small intestine	41 NX
Rectum	40 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	16 NX
Placenta	16 NX

Fibroblasts	6 NX
Prostate	14 NX
Skin	7 NX
Lung	4 NX
Heart muscle	1 NX
Placenta	1 NX

Glandular cells	119 NX
Prostate	119 NX

Granulocytes	0 NX
Colon	0 NX
Lung	0 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	8 NX
Placenta	8 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	13 NX
Colon	17 NX
Rectum	9 NX

Ito cells	7 NX
Liver	7 NX

Kupffer cells	31 NX
Liver	31 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	0 NX
Testis	0 NX

Macrophages	8 NX
Prostate	35 NX
Kidney	16 NX
Skin	9 NX
Lung	8 NX
Testis	7 NX
Pancreas	2 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	41 NX
Pancreas	41 NX

Mucus-secreting cells	26 NX
Colon	43 NX
Small intestine	23 NX
Rectum	23 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	21 NX
Pancreas	21 NX

Paneth cells	14 NX
Rectum	25 NX
Colon	14 NX
Small intestine	14 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	5 NX
Heart muscle	16 NX
Prostate	14 NX
Skin	5 NX
Pancreas	1 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	124 NX
Skin	124 NX

Syncytiotrophoblasts	69 NX
Placenta	69 NX

T-cells	3 NX
Prostate	9 NX
Skin	3 NX
Lung	3 NX
Colon	3 NX
Liver	1 NX
Kidney	1 NX

Undifferentiated cells	38 NX
Colon	44 NX
Small intestine	38 NX
Rectum	35 NX

Urothelial cells	139 NX
Prostate	139 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.