Cell type atlas - CTSL - The Human Protein Atlas

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CTSL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTSL
Gene descriptionⁱ Full gene name according to HGNC.	Cathepsin L
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells, Cytotrophoblasts, Extravillous trophoblasts, Ito cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells, Cytotrophoblasts, Extravillous trophoblasts, Ito cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	61 NX
Lung	61 NX

B-cells	39 NX
Colon	49 NX
Liver	39 NX
Kidney	9 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	34 NX
Skin	34 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	87 NX
Heart muscle	87 NX

Cholangiocytes	84 NX
Liver	84 NX

Ciliated cells	56 NX
Lung	56 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	72 NX
Kidney	72 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	936 NX
Placenta	936 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	78 NX
Pancreas	78 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	76 NX
Liver	389 NX
Placenta	157 NX
Lung	114 NX
Prostate	104 NX
Skin	77 NX
Eye	74 NX
Heart muscle	67 NX
Pancreas	61 NX
Testis	39 NX

Enterocytes	9 NX
Rectum	22 NX
Colon	9 NX
Small intestine	7 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	82 NX
Pancreas	82 NX

Extravillous trophoblasts	843 NX
Placenta	843 NX

Fibroblasts	226 NX
Prostate	382 NX
Placenta	325 NX
Skin	187 NX
Lung	142 NX
Heart muscle	128 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	28 NX
Lung	47 NX
Colon	9 NX

Hepatocytes	101 NX
Liver	101 NX

Hofbauer cells	1005 NX
Placenta	1005 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	11 NX
Rectum	19 NX
Colon	3 NX

Ito cells	673 NX
Liver	673 NX

Kupffer cells	182 NX
Liver	182 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	145 NX
Testis	145 NX

Macrophages	481 NX
Pancreas	3767 NX
Prostate	590 NX
Lung	489 NX
Kidney	481 NX
Testis	78 NX
Skin	76 NX

Melanocytes	61 NX
Skin	61 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	20 NX
Pancreas	20 NX

Mucus-secreting cells	8 NX
Rectum	12 NX
Colon	9 NX
Small intestine	2 NX

Muller glia cells	79 NX
Eye	79 NX

Pancreatic endocrine cells	55 NX
Pancreas	55 NX

Paneth cells	3 NX
Rectum	12 NX
Colon	3 NX
Small intestine	0 NX

Peritubular cells	176 NX
Testis	176 NX

Proximal tubular cells	108 NX
Kidney	108 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	103 NX
Prostate	240 NX
Pancreas	219 NX
Skin	100 NX
Heart muscle	89 NX

Spermatocytes	144 NX
Testis	144 NX

Spermatogonia	46 NX
Testis	46 NX

Suprabasal keratinocytes	30 NX
Skin	30 NX

Syncytiotrophoblasts	1291 NX
Placenta	1291 NX

T-cells	15 NX
Lung	37 NX
Skin	21 NX
Liver	18 NX
Kidney	15 NX
Prostate	9 NX
Colon	2 NX

Undifferentiated cells	9 NX
Rectum	14 NX
Colon	7 NX
Small intestine	4 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.