Cell type atlas - TPP2 - The Human Protein Atlas

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TPP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPP2
Gene descriptionⁱ Full gene name according to HGNC.	Tripeptidyl peptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	24 NX
Liver	29 NX
Colon	21 NX
Kidney	5 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	51 NX
Lung	51 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	69 NX
Eye	69 NX

Cytotrophoblasts	24 NX
Placenta	24 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	16 NX
Pancreas	16 NX

Early spermatids	629 NX
Testis	629 NX

Endothelial cells	16 NX
Pancreas	29 NX
Heart muscle	22 NX
Eye	19 NX
Testis	16 NX
Lung	15 NX
Prostate	15 NX
Skin	14 NX
Placenta	11 NX
Liver	7 NX

Enterocytes	10 NX
Rectum	10 NX
Colon	10 NX
Small intestine	9 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	8 NX
Pancreas	8 NX

Extravillous trophoblasts	23 NX
Placenta	23 NX

Fibroblasts	16 NX
Lung	36 NX
Heart muscle	28 NX
Placenta	16 NX
Skin	16 NX
Prostate	15 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	37 NX
Lung	47 NX
Colon	28 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	19 NX
Rectum	21 NX
Colon	17 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	21 NX
Liver	21 NX

Late spermatids	647 NX
Testis	647 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	22 NX
Testis	42 NX
Lung	35 NX
Kidney	24 NX
Prostate	20 NX
Skin	19 NX
Pancreas	12 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	16 NX
Pancreas	16 NX

Mucus-secreting cells	17 NX
Rectum	20 NX
Colon	18 NX
Small intestine	9 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	12 NX
Pancreas	12 NX

Paneth cells	15 NX
Small intestine	18 NX
Rectum	15 NX
Colon	12 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	18 NX
Heart muscle	24 NX
Skin	18 NX
Pancreas	16 NX
Prostate	13 NX

Spermatocytes	51 NX
Testis	51 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	28 NX
Placenta	28 NX

T-cells	28 NX
Lung	48 NX
Colon	35 NX
Liver	28 NX
Kidney	24 NX
Prostate	13 NX
Skin	13 NX

Undifferentiated cells	18 NX
Rectum	23 NX
Small intestine	15 NX
Colon	11 NX

Urothelial cells	17 NX
Prostate	17 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.