Cell type atlas - EMP1 - The Human Protein Atlas

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EMP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EMP1
Gene descriptionⁱ Full gene name according to HGNC.	Epithelial membrane protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Basal keratinocytes, Suprabasal keratinocytes, Fibroblasts, Melanocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1, fHDF/TERT166, HaCaT)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Basal keratinocytes, Suprabasal keratinocytes, Fibroblasts, Melanocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	191 NX
Lung	191 NX

Alveolar cells type 2	90 NX
Lung	90 NX

B-cells	3 NX
Colon	12 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	199 NX
Prostate	199 NX

Basal keratinocytes	617 NX
Skin	617 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	3 NX
Liver	3 NX

Ciliated cells	87 NX
Lung	87 NX

Club cells	248 NX
Lung	248 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	18 NX
Pancreas	18 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	294 NX
Lung	2144 NX
Prostate	1221 NX
Skin	1147 NX
Pancreas	294 NX
Testis	270 NX
Placenta	243 NX
Heart muscle	202 NX
Eye	160 NX
Liver	151 NX

Enterocytes	60 NX
Colon	474 NX
Rectum	207 NX
Small intestine	45 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	4 NX
Pancreas	4 NX

Extravillous trophoblasts	2 NX
Placenta	2 NX

Fibroblasts	490 NX
Lung	864 NX
Prostate	704 NX
Skin	675 NX
Heart muscle	268 NX
Placenta	24 NX

Glandular cells	352 NX
Prostate	352 NX

Granulocytes	47 NX
Lung	93 NX
Colon	0 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	42 NX
Placenta	42 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	46 NX
Colon	75 NX
Rectum	16 NX

Ito cells	128 NX
Liver	128 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	65 NX
Testis	65 NX

Macrophages	94 NX
Skin	354 NX
Lung	224 NX
Pancreas	101 NX
Prostate	57 NX
Testis	50 NX
Kidney	26 NX

Melanocytes	449 NX
Skin	449 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	7 NX
Pancreas	7 NX

Mucus-secreting cells	4 NX
Colon	27 NX
Rectum	4 NX
Small intestine	3 NX

Muller glia cells	3 NX
Eye	3 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	27 NX
Colon	867 NX
Rectum	27 NX
Small intestine	7 NX

Peritubular cells	103 NX
Testis	103 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	173 NX
Prostate	469 NX
Skin	173 NX
Pancreas	173 NX
Heart muscle	61 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	601 NX
Skin	601 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	5 NX
Skin	124 NX
Lung	46 NX
Prostate	26 NX
Colon	19 NX
Kidney	5 NX
Liver	0 NX

Undifferentiated cells	6 NX
Colon	53 NX
Small intestine	8 NX
Rectum	4 NX

Urothelial cells	927 NX
Prostate	927 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.