Cell type atlas - LDHA - The Human Protein Atlas

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LDHA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LDHA
Gene descriptionⁱ Full gene name according to HGNC.	Lactate dehydrogenase A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	69 NX
Lung	69 NX

Alveolar cells type 2	192 NX
Lung	192 NX

B-cells	171 NX
Liver	398 NX
Colon	218 NX
Kidney	125 NX

Basal glandular cells	332 NX
Prostate	332 NX

Basal keratinocytes	1953 NX
Skin	1953 NX

Bipolar cells	416 NX
Eye	416 NX

Cardiomyocytes	223 NX
Heart muscle	223 NX

Cholangiocytes	143 NX
Liver	143 NX

Ciliated cells	86 NX
Lung	86 NX

Club cells	188 NX
Lung	188 NX

Collecting duct cells	293 NX
Kidney	293 NX

Cone photoreceptor cells	137 NX
Eye	137 NX

Cytotrophoblasts	475 NX
Placenta	475 NX

Distal tubular cells	368 NX
Kidney	368 NX

Ductal cells	1060 NX
Pancreas	1060 NX

Early spermatids	147 NX
Testis	147 NX

Endothelial cells	475 NX
Prostate	1038 NX
Skin	797 NX
Pancreas	580 NX
Testis	551 NX
Placenta	496 NX
Eye	445 NX
Liver	252 NX
Lung	181 NX
Heart muscle	170 NX

Enterocytes	671 NX
Small intestine	1433 NX
Rectum	750 NX
Colon	451 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	1351 NX
Pancreas	1351 NX

Extravillous trophoblasts	1781 NX
Placenta	1781 NX

Fibroblasts	726 NX
Skin	829 NX
Prostate	745 NX
Placenta	639 NX
Lung	610 NX
Heart muscle	246 NX

Glandular cells	281 NX
Prostate	281 NX

Granulocytes	256 NX
Colon	266 NX
Lung	247 NX

Hepatocytes	438 NX
Liver	438 NX

Hofbauer cells	608 NX
Placenta	608 NX

Horizontal cells	486 NX
Eye	486 NX

Intestinal endocrine cells	44 NX
Rectum	47 NX
Colon	41 NX

Ito cells	182 NX
Liver	182 NX

Kupffer cells	215 NX
Liver	215 NX

Late spermatids	106 NX
Testis	106 NX

Leydig cells	266 NX
Testis	266 NX

Macrophages	428 NX
Skin	758 NX
Pancreas	700 NX
Prostate	578 NX
Testis	457 NX
Kidney	343 NX
Lung	247 NX

Melanocytes	1117 NX
Skin	1117 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1463 NX
Pancreas	1463 NX

Mucus-secreting cells	177 NX
Colon	366 NX
Small intestine	253 NX
Rectum	155 NX

Muller glia cells	317 NX
Eye	317 NX

Pancreatic endocrine cells	1381 NX
Pancreas	1381 NX

Paneth cells	488 NX
Colon	783 NX
Small intestine	488 NX
Rectum	320 NX

Peritubular cells	193 NX
Testis	193 NX

Proximal tubular cells	409 NX
Kidney	409 NX

Rod photoreceptor cells	355 NX
Eye	355 NX

Sertoli cells	188 NX
Testis	188 NX

Smooth muscle cells	1240 NX
Pancreas	1892 NX
Skin	1274 NX
Prostate	1240 NX
Heart muscle	175 NX

Spermatocytes	103 NX
Testis	103 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	1506 NX
Skin	1506 NX

Syncytiotrophoblasts	420 NX
Placenta	420 NX

T-cells	214 NX
Skin	882 NX
Colon	390 NX
Kidney	328 NX
Prostate	214 NX
Lung	204 NX
Liver	174 NX

Undifferentiated cells	252 NX
Colon	467 NX
Small intestine	257 NX
Rectum	194 NX

Urothelial cells	385 NX
Prostate	385 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.