Cell type atlas - IAH1 - The Human Protein Atlas

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IAH1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IAH1
Gene descriptionⁱ Full gene name according to HGNC.	Isoamyl acetate hydrolyzing esterase 1 (putative)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	56 NX
Kidney	76 NX
Colon	70 NX
Liver	21 NX

Basal glandular cells	84 NX
Prostate	84 NX

Basal keratinocytes	80 NX
Skin	80 NX

Bipolar cells	32 NX
Eye	32 NX

Cardiomyocytes	40 NX
Heart muscle	40 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	64 NX
Placenta	64 NX

Distal tubular cells	78 NX
Kidney	78 NX

Ductal cells	60 NX
Pancreas	60 NX

Early spermatids	336 NX
Testis	336 NX

Endothelial cells	32 NX
Skin	43 NX
Testis	42 NX
Eye	34 NX
Placenta	32 NX
Liver	32 NX
Pancreas	29 NX
Prostate	29 NX
Lung	12 NX
Heart muscle	12 NX

Enterocytes	42 NX
Small intestine	59 NX
Rectum	41 NX
Colon	24 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	68 NX
Pancreas	68 NX

Extravillous trophoblasts	90 NX
Placenta	90 NX

Fibroblasts	85 NX
Skin	95 NX
Placenta	89 NX
Prostate	62 NX
Heart muscle	40 NX
Lung	36 NX

Glandular cells	54 NX
Prostate	54 NX

Granulocytes	36 NX
Colon	37 NX
Lung	35 NX

Hepatocytes	49 NX
Liver	49 NX

Hofbauer cells	78 NX
Placenta	78 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	25 NX
Colon	31 NX
Rectum	19 NX

Ito cells	34 NX
Liver	34 NX

Kupffer cells	62 NX
Liver	62 NX

Late spermatids	365 NX
Testis	365 NX

Leydig cells	87 NX
Testis	87 NX

Macrophages	75 NX
Testis	96 NX
Prostate	96 NX
Skin	84 NX
Kidney	68 NX
Pancreas	61 NX
Lung	41 NX

Melanocytes	88 NX
Skin	88 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	140 NX
Pancreas	140 NX

Mucus-secreting cells	25 NX
Small intestine	27 NX
Rectum	27 NX
Colon	19 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	73 NX
Pancreas	73 NX

Paneth cells	32 NX
Rectum	44 NX
Small intestine	32 NX
Colon	26 NX

Peritubular cells	69 NX
Testis	69 NX

Proximal tubular cells	109 NX
Kidney	109 NX

Rod photoreceptor cells	51 NX
Eye	51 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	77 NX
Skin	78 NX
Pancreas	77 NX
Prostate	60 NX
Heart muscle	15 NX

Spermatocytes	215 NX
Testis	215 NX

Spermatogonia	47 NX
Testis	47 NX

Suprabasal keratinocytes	84 NX
Skin	84 NX

Syncytiotrophoblasts	37 NX
Placenta	37 NX

T-cells	66 NX
Skin	96 NX
Kidney	80 NX
Colon	79 NX
Liver	62 NX
Lung	45 NX
Prostate	44 NX

Undifferentiated cells	46 NX
Rectum	47 NX
Colon	40 NX
Small intestine	39 NX

Urothelial cells	87 NX
Prostate	87 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.