Cell type atlas - LPIN1 - The Human Protein Atlas

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LPIN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LPIN1
Gene descriptionⁱ Full gene name according to HGNC.	Lipin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	49 NX
Lung	49 NX

B-cells	23 NX
Colon	97 NX
Liver	23 NX
Kidney	9 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	41 NX
Eye	41 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	62 NX
Lung	62 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	81 NX
Eye	81 NX

Cytotrophoblasts	7 NX
Placenta	7 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	19 NX
Pancreas	19 NX

Early spermatids	315 NX
Testis	315 NX

Endothelial cells	25 NX
Prostate	67 NX
Lung	41 NX
Testis	31 NX
Pancreas	29 NX
Heart muscle	27 NX
Liver	22 NX
Skin	19 NX
Eye	14 NX
Placenta	4 NX

Enterocytes	10 NX
Colon	15 NX
Rectum	11 NX
Small intestine	5 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	24 NX
Pancreas	24 NX

Extravillous trophoblasts	5 NX
Placenta	5 NX

Fibroblasts	25 NX
Heart muscle	41 NX
Prostate	40 NX
Lung	25 NX
Skin	22 NX
Placenta	20 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	34 NX
Lung	49 NX
Colon	18 NX

Hepatocytes	22 NX
Liver	22 NX

Hofbauer cells	8 NX
Placenta	8 NX

Horizontal cells	46 NX
Eye	46 NX

Intestinal endocrine cells	35 NX
Colon	58 NX
Rectum	12 NX

Ito cells	15 NX
Liver	15 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	1311 NX
Testis	1311 NX

Leydig cells	110 NX
Testis	110 NX

Macrophages	27 NX
Prostate	39 NX
Testis	33 NX
Lung	31 NX
Skin	26 NX
Kidney	8 NX
Pancreas	0 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	7 NX
Pancreas	7 NX

Mucus-secreting cells	24 NX
Colon	26 NX
Rectum	22 NX
Small intestine	22 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	12 NX
Colon	63 NX
Rectum	12 NX
Small intestine	4 NX

Peritubular cells	169 NX
Testis	169 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	47 NX
Eye	47 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	21 NX
Prostate	30 NX
Heart muscle	29 NX
Skin	20 NX
Pancreas	8 NX

Spermatocytes	18 NX
Testis	18 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	11 NX
Skin	11 NX

Syncytiotrophoblasts	10 NX
Placenta	10 NX

T-cells	58 NX
Colon	131 NX
Lung	79 NX
Liver	60 NX
Skin	58 NX
Prostate	44 NX
Kidney	29 NX

Undifferentiated cells	14 NX
Colon	27 NX
Rectum	14 NX
Small intestine	4 NX

Urothelial cells	27 NX
Prostate	27 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.