Cell type atlas - SLC38A2 - The Human Protein Atlas

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SLC38A2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC38A2
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 38 member 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTERT-HME1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	94 NX
Lung	94 NX

B-cells	77 NX
Liver	153 NX
Colon	70 NX
Kidney	45 NX

Basal glandular cells	115 NX
Prostate	115 NX

Basal keratinocytes	993 NX
Skin	993 NX

Bipolar cells	38 NX
Eye	38 NX

Cardiomyocytes	138 NX
Heart muscle	138 NX

Cholangiocytes	99 NX
Liver	99 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	54 NX
Kidney	54 NX

Cone photoreceptor cells	67 NX
Eye	67 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	36 NX
Pancreas	36 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	142 NX
Skin	467 NX
Liver	382 NX
Prostate	200 NX
Placenta	173 NX
Eye	141 NX
Heart muscle	132 NX
Lung	99 NX
Testis	89 NX
Pancreas	39 NX

Enterocytes	79 NX
Colon	129 NX
Rectum	72 NX
Small intestine	56 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	41 NX
Placenta	41 NX

Fibroblasts	160 NX
Skin	326 NX
Prostate	164 NX
Lung	160 NX
Heart muscle	138 NX
Placenta	95 NX

Glandular cells	158 NX
Prostate	158 NX

Granulocytes	79 NX
Lung	93 NX
Colon	64 NX

Hepatocytes	246 NX
Liver	246 NX

Hofbauer cells	48 NX
Placenta	48 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	74 NX
Colon	119 NX
Rectum	28 NX

Ito cells	234 NX
Liver	234 NX

Kupffer cells	167 NX
Liver	166 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	244 NX
Testis	244 NX

Macrophages	111 NX
Skin	249 NX
Prostate	145 NX
Testis	104 NX
Lung	91 NX
Kidney	74 NX
Pancreas	35 NX

Melanocytes	238 NX
Skin	238 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	21 NX
Pancreas	21 NX

Mucus-secreting cells	108 NX
Colon	257 NX
Rectum	101 NX
Small intestine	100 NX

Muller glia cells	73 NX
Eye	73 NX

Pancreatic endocrine cells	64 NX
Pancreas	64 NX

Paneth cells	63 NX
Colon	112 NX
Rectum	63 NX
Small intestine	49 NX

Peritubular cells	80 NX
Testis	80 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	74 NX
Eye	74 NX

Sertoli cells	278 NX
Testis	278 NX

Smooth muscle cells	221 NX
Skin	357 NX
Heart muscle	221 NX
Prostate	184 NX
Pancreas	48 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	15 NX
Testis	15 NX

Suprabasal keratinocytes	943 NX
Skin	943 NX

Syncytiotrophoblasts	32 NX
Placenta	32 NX

T-cells	137 NX
Skin	222 NX
Liver	155 NX
Colon	137 NX
Lung	114 NX
Prostate	105 NX
Kidney	78 NX

Undifferentiated cells	68 NX
Colon	163 NX
Rectum	68 NX
Small intestine	52 NX

Urothelial cells	106 NX
Prostate	106 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.