Cell type atlas - EIF2S1 - The Human Protein Atlas

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EIF2S1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF2S1
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 2 subunit alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	35 NX
Colon	43 NX
Liver	35 NX
Kidney	27 NX

Basal glandular cells	67 NX
Prostate	67 NX

Basal keratinocytes	127 NX
Skin	127 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	85 NX
Heart muscle	85 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	44 NX
Lung	44 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	70 NX
Placenta	70 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	77 NX
Pancreas	77 NX

Early spermatids	64 NX
Testis	64 NX

Endothelial cells	51 NX
Pancreas	129 NX
Prostate	93 NX
Heart muscle	58 NX
Skin	54 NX
Placenta	51 NX
Lung	47 NX
Testis	44 NX
Eye	38 NX
Liver	32 NX

Enterocytes	22 NX
Small intestine	22 NX
Rectum	22 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	55 NX
Pancreas	55 NX

Extravillous trophoblasts	82 NX
Placenta	82 NX

Fibroblasts	48 NX
Heart muscle	75 NX
Prostate	68 NX
Lung	48 NX
Placenta	47 NX
Skin	40 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	35 NX
Colon	37 NX
Lung	33 NX

Hepatocytes	38 NX
Liver	38 NX

Hofbauer cells	63 NX
Placenta	63 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	13 NX
Colon	20 NX
Rectum	5 NX

Ito cells	24 NX
Liver	24 NX

Kupffer cells	40 NX
Liver	40 NX

Late spermatids	23 NX
Testis	23 NX

Leydig cells	29 NX
Testis	29 NX

Macrophages	44 NX
Pancreas	75 NX
Lung	45 NX
Kidney	43 NX
Prostate	37 NX
Skin	36 NX
Testis	33 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	67 NX
Pancreas	67 NX

Mucus-secreting cells	24 NX
Colon	35 NX
Small intestine	22 NX
Rectum	18 NX

Muller glia cells	21 NX
Eye	21 NX

Pancreatic endocrine cells	61 NX
Pancreas	61 NX

Paneth cells	12 NX
Rectum	31 NX
Colon	12 NX
Small intestine	7 NX

Peritubular cells	38 NX
Testis	38 NX

Proximal tubular cells	53 NX
Kidney	53 NX

Rod photoreceptor cells	26 NX
Eye	26 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	79 NX
Pancreas	125 NX
Heart muscle	98 NX
Prostate	79 NX
Skin	57 NX

Spermatocytes	212 NX
Testis	212 NX

Spermatogonia	74 NX
Testis	74 NX

Suprabasal keratinocytes	114 NX
Skin	114 NX

Syncytiotrophoblasts	78 NX
Placenta	78 NX

T-cells	42 NX
Prostate	61 NX
Skin	55 NX
Colon	53 NX
Lung	42 NX
Kidney	37 NX
Liver	26 NX

Undifferentiated cells	34 NX
Small intestine	42 NX
Colon	41 NX
Rectum	29 NX

Urothelial cells	65 NX
Prostate	65 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.