Cell type atlas - BTG1 - The Human Protein Atlas

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BTG1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BTG1
Gene descriptionⁱ Full gene name according to HGNC.	BTG anti-proliferation factor 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	164 NX
Lung	164 NX

B-cells	1134 NX
Kidney	1221 NX
Colon	1047 NX
Liver	797 NX

Basal glandular cells	898 NX
Prostate	898 NX

Basal keratinocytes	2444 NX
Skin	2444 NX

Bipolar cells	509 NX
Eye	509 NX

Cardiomyocytes	100 NX
Heart muscle	100 NX

Cholangiocytes	696 NX
Liver	696 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	166 NX
Kidney	166 NX

Cone photoreceptor cells	185 NX
Eye	185 NX

Cytotrophoblasts	345 NX
Placenta	345 NX

Distal tubular cells	272 NX
Kidney	272 NX

Ductal cells	358 NX
Pancreas	357 NX

Early spermatids	307 NX
Testis	307 NX

Endothelial cells	259 NX
Skin	1720 NX
Prostate	1279 NX
Testis	900 NX
Eye	868 NX
Placenta	259 NX
Liver	216 NX
Heart muscle	144 NX
Pancreas	143 NX
Lung	88 NX

Enterocytes	666 NX
Colon	815 NX
Small intestine	521 NX
Rectum	383 NX

Erythroid cells	140 NX
Liver	140 NX

Exocrine glandular cells	222 NX
Pancreas	222 NX

Extravillous trophoblasts	261 NX
Placenta	261 NX

Fibroblasts	226 NX
Prostate	1579 NX
Skin	821 NX
Placenta	165 NX
Heart muscle	93 NX
Lung	89 NX

Glandular cells	729 NX
Prostate	729 NX

Granulocytes	289 NX
Colon	468 NX
Lung	109 NX

Hepatocytes	235 NX
Liver	235 NX

Hofbauer cells	359 NX
Placenta	359 NX

Horizontal cells	401 NX
Eye	401 NX

Intestinal endocrine cells	434 NX
Colon	489 NX
Rectum	379 NX

Ito cells	206 NX
Liver	206 NX

Kupffer cells	468 NX
Liver	468 NX

Late spermatids	135 NX
Testis	135 NX

Leydig cells	266 NX
Testis	266 NX

Macrophages	683 NX
Prostate	3276 NX
Testis	1837 NX
Skin	1720 NX
Kidney	775 NX
Lung	227 NX
Pancreas	159 NX

Melanocytes	933 NX
Skin	933 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1485 NX
Pancreas	1485 NX

Mucus-secreting cells	192 NX
Colon	586 NX
Small intestine	255 NX
Rectum	159 NX

Muller glia cells	768 NX
Eye	768 NX

Pancreatic endocrine cells	308 NX
Pancreas	308 NX

Paneth cells	596 NX
Colon	941 NX
Small intestine	596 NX
Rectum	263 NX

Peritubular cells	227 NX
Testis	227 NX

Proximal tubular cells	96 NX
Kidney	96 NX

Rod photoreceptor cells	343 NX
Eye	343 NX

Sertoli cells	530 NX
Testis	530 NX

Smooth muscle cells	1117 NX
Prostate	1828 NX
Skin	1204 NX
Heart muscle	227 NX
Pancreas	105 NX

Spermatocytes	69 NX
Testis	69 NX

Spermatogonia	114 NX
Testis	114 NX

Suprabasal keratinocytes	2626 NX
Skin	2626 NX

Syncytiotrophoblasts	1123 NX
Placenta	1123 NX

T-cells	1563 NX
Prostate	3988 NX
Skin	3105 NX
Kidney	1563 NX
Liver	1469 NX
Colon	1041 NX
Lung	163 NX

Undifferentiated cells	226 NX
Colon	623 NX
Small intestine	262 NX
Rectum	199 NX

Urothelial cells	1040 NX
Prostate	1040 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.