Cell type atlas - MKRN1 - The Human Protein Atlas

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MKRN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MKRN1
Gene descriptionⁱ Full gene name according to HGNC.	Makorin ring finger protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	57 NX
Colon	99 NX
Liver	57 NX
Kidney	45 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	73 NX
Skin	73 NX

Bipolar cells	59 NX
Eye	59 NX

Cardiomyocytes	51 NX
Heart muscle	51 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	33 NX
Eye	33 NX

Cytotrophoblasts	63 NX
Placenta	63 NX

Distal tubular cells	88 NX
Kidney	88 NX

Ductal cells	56 NX
Pancreas	56 NX

Early spermatids	228 NX
Testis	228 NX

Endothelial cells	34 NX
Pancreas	39 NX
Eye	38 NX
Skin	36 NX
Prostate	35 NX
Testis	34 NX
Heart muscle	29 NX
Placenta	29 NX
Liver	29 NX
Lung	20 NX

Enterocytes	112 NX
Rectum	169 NX
Colon	121 NX
Small intestine	95 NX

Erythroid cells	257 NX
Liver	257 NX

Exocrine glandular cells	60 NX
Pancreas	60 NX

Extravillous trophoblasts	77 NX
Placenta	77 NX

Fibroblasts	47 NX
Skin	59 NX
Prostate	55 NX
Heart muscle	36 NX
Placenta	34 NX
Lung	24 NX

Glandular cells	75 NX
Prostate	74 NX

Granulocytes	37 NX
Colon	46 NX
Lung	28 NX

Hepatocytes	39 NX
Liver	39 NX

Hofbauer cells	53 NX
Placenta	53 NX

Horizontal cells	113 NX
Eye	113 NX

Intestinal endocrine cells	94 NX
Rectum	112 NX
Colon	75 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	92 NX
Liver	92 NX

Late spermatids	263 NX
Testis	263 NX

Leydig cells	62 NX
Testis	62 NX

Macrophages	68 NX
Kidney	84 NX
Skin	79 NX
Prostate	79 NX
Testis	63 NX
Lung	49 NX
Pancreas	37 NX

Melanocytes	66 NX
Skin	66 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	87 NX
Pancreas	87 NX

Mucus-secreting cells	101 NX
Rectum	104 NX
Small intestine	95 NX
Colon	90 NX

Muller glia cells	52 NX
Eye	52 NX

Pancreatic endocrine cells	53 NX
Pancreas	53 NX

Paneth cells	124 NX
Rectum	144 NX
Colon	124 NX
Small intestine	112 NX

Peritubular cells	59 NX
Testis	59 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	43 NX
Eye	43 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	50 NX
Prostate	71 NX
Skin	60 NX
Pancreas	29 NX
Heart muscle	25 NX

Spermatocytes	153 NX
Testis	153 NX

Spermatogonia	47 NX
Testis	47 NX

Suprabasal keratinocytes	83 NX
Skin	83 NX

Syncytiotrophoblasts	115 NX
Placenta	115 NX

T-cells	66 NX
Skin	117 NX
Liver	74 NX
Colon	69 NX
Kidney	50 NX
Prostate	48 NX
Lung	35 NX

Undifferentiated cells	96 NX
Rectum	100 NX
Colon	94 NX
Small intestine	83 NX

Urothelial cells	101 NX
Prostate	101 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.