Cell type atlas - HSPBP1 - The Human Protein Atlas

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HSPBP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSPBP1
Gene descriptionⁱ Full gene name according to HGNC.	HSPA (Hsp70) binding protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HEK93)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	27 NX
Liver	47 NX
Colon	16 NX
Kidney	13 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	11 NX
Heart muscle	11 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	45 NX
Placenta	45 NX

Distal tubular cells	61 NX
Kidney	61 NX

Ductal cells	56 NX
Pancreas	56 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	15 NX
Pancreas	50 NX
Placenta	24 NX
Skin	16 NX
Testis	15 NX
Prostate	15 NX
Lung	12 NX
Eye	12 NX
Liver	11 NX
Heart muscle	9 NX

Enterocytes	24 NX
Colon	73 NX
Small intestine	21 NX
Rectum	16 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	40 NX
Pancreas	40 NX

Extravillous trophoblasts	45 NX
Placenta	45 NX

Fibroblasts	21 NX
Placenta	36 NX
Lung	32 NX
Prostate	21 NX
Skin	18 NX
Heart muscle	8 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	10 NX
Lung	12 NX
Colon	9 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	13 NX
Eye	13 NX

Intestinal endocrine cells	22 NX
Colon	34 NX
Rectum	9 NX

Ito cells	7 NX
Liver	7 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	14 NX
Pancreas	26 NX
Kidney	23 NX
Skin	17 NX
Lung	14 NX
Prostate	13 NX
Testis	8 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	35 NX
Pancreas	35 NX

Mucus-secreting cells	30 NX
Colon	34 NX
Rectum	28 NX
Small intestine	20 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	42 NX
Colon	43 NX
Rectum	42 NX
Small intestine	35 NX

Peritubular cells	17 NX
Testis	17 NX

Proximal tubular cells	46 NX
Kidney	46 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	21 NX
Pancreas	54 NX
Prostate	25 NX
Skin	20 NX
Heart muscle	3 NX

Spermatocytes	34 NX
Testis	34 NX

Spermatogonia	24 NX
Testis	24 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	31 NX
Placenta	31 NX

T-cells	16 NX
Kidney	24 NX
Colon	19 NX
Prostate	18 NX
Lung	16 NX
Liver	15 NX
Skin	8 NX

Undifferentiated cells	47 NX
Colon	68 NX
Small intestine	49 NX
Rectum	37 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.