Cell type atlas - MPRIP - The Human Protein Atlas

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MPRIP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPRIP
Gene descriptionⁱ Full gene name according to HGNC.	Myosin phosphatase Rho interacting protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-reg)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	22 NX
Kidney	27 NX
Liver	23 NX
Colon	11 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	108 NX
Eye	108 NX

Cardiomyocytes	52 NX
Heart muscle	52 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	77 NX
Eye	77 NX

Cytotrophoblasts	22 NX
Placenta	22 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	26 NX
Testis	26 NX

Endothelial cells	47 NX
Eye	86 NX
Pancreas	82 NX
Prostate	58 NX
Heart muscle	56 NX
Liver	47 NX
Skin	39 NX
Testis	37 NX
Placenta	37 NX
Lung	35 NX

Enterocytes	27 NX
Rectum	54 NX
Colon	27 NX
Small intestine	25 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	25 NX
Pancreas	25 NX

Extravillous trophoblasts	31 NX
Placenta	31 NX

Fibroblasts	38 NX
Skin	43 NX
Lung	39 NX
Placenta	35 NX
Heart muscle	34 NX
Prostate	29 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	16 NX
Colon	18 NX
Lung	14 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	11 NX
Placenta	11 NX

Horizontal cells	92 NX
Eye	92 NX

Intestinal endocrine cells	22 NX
Colon	27 NX
Rectum	16 NX

Ito cells	34 NX
Liver	34 NX

Kupffer cells	9 NX
Liver	9 NX

Late spermatids	23 NX
Testis	23 NX

Leydig cells	27 NX
Testis	27 NX

Macrophages	15 NX
Skin	17 NX
Prostate	16 NX
Testis	15 NX
Lung	13 NX
Pancreas	9 NX
Kidney	5 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	2 NX
Pancreas	2 NX

Mucus-secreting cells	17 NX
Rectum	19 NX
Small intestine	15 NX
Colon	10 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	60 NX
Pancreas	60 NX

Paneth cells	23 NX
Rectum	27 NX
Colon	23 NX
Small intestine	21 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	46 NX
Eye	46 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	91 NX
Heart muscle	127 NX
Skin	106 NX
Prostate	67 NX
Pancreas	39 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	27 NX
Testis	27 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	25 NX
Colon	45 NX
Skin	44 NX
Liver	28 NX
Kidney	24 NX
Lung	13 NX
Prostate	9 NX

Undifferentiated cells	26 NX
Rectum	29 NX
Small intestine	22 NX
Colon	11 NX

Urothelial cells	106 NX
Prostate	106 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.