Cell type atlas - OSER1 - The Human Protein Atlas

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OSER1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OSER1
Gene descriptionⁱ Full gene name according to HGNC.	Oxidative stress responsive serine rich 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	24 NX
Colon	78 NX
Kidney	27 NX
Liver	18 NX

Basal glandular cells	120 NX
Prostate	120 NX

Basal keratinocytes	230 NX
Skin	230 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	34 NX
Heart muscle	34 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	34 NX
Placenta	34 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	38 NX
Pancreas	38 NX

Early spermatids	723 NX
Testis	723 NX

Endothelial cells	32 NX
Prostate	72 NX
Skin	56 NX
Pancreas	43 NX
Heart muscle	32 NX
Liver	32 NX
Testis	30 NX
Placenta	25 NX
Lung	18 NX
Eye	17 NX

Enterocytes	56 NX
Colon	66 NX
Small intestine	53 NX
Rectum	39 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	34 NX
Prostate	122 NX
Skin	69 NX
Lung	34 NX
Placenta	25 NX
Heart muscle	21 NX

Glandular cells	80 NX
Prostate	80 NX

Granulocytes	33 NX
Colon	55 NX
Lung	12 NX

Hepatocytes	26 NX
Liver	26 NX

Hofbauer cells	38 NX
Placenta	38 NX

Horizontal cells	11 NX
Eye	11 NX

Intestinal endocrine cells	47 NX
Colon	71 NX
Rectum	23 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	1504 NX
Testis	1504 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	43 NX
Prostate	131 NX
Skin	81 NX
Pancreas	44 NX
Testis	42 NX
Kidney	27 NX
Lung	26 NX

Melanocytes	73 NX
Skin	73 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	117 NX
Pancreas	117 NX

Mucus-secreting cells	30 NX
Small intestine	37 NX
Colon	31 NX
Rectum	27 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	42 NX
Pancreas	42 NX

Paneth cells	46 NX
Colon	150 NX
Small intestine	46 NX
Rectum	39 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	26 NX
Kidney	26 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	50 NX
Prostate	81 NX
Skin	72 NX
Pancreas	34 NX
Heart muscle	22 NX

Spermatocytes	76 NX
Testis	76 NX

Spermatogonia	56 NX
Testis	56 NX

Suprabasal keratinocytes	173 NX
Skin	173 NX

Syncytiotrophoblasts	145 NX
Placenta	145 NX

T-cells	36 NX
Skin	82 NX
Prostate	61 NX
Colon	57 NX
Lung	36 NX
Kidney	31 NX
Liver	30 NX

Undifferentiated cells	35 NX
Small intestine	61 NX
Colon	55 NX
Rectum	30 NX

Urothelial cells	99 NX
Prostate	99 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.