Cell type atlas - PTPRA - The Human Protein Atlas

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PTPRA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PTPRA
Gene descriptionⁱ Full gene name according to HGNC.	Protein tyrosine phosphatase, receptor type A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	16 NX
Lung	16 NX

B-cells	29 NX
Colon	37 NX
Liver	25 NX
Kidney	22 NX

Basal glandular cells	30 NX
Prostate	30 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	88 NX
Eye	88 NX

Cardiomyocytes	7 NX
Heart muscle	7 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	25 NX
Placenta	25 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	13 NX
Pancreas	13 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	27 NX
Liver	54 NX
Eye	47 NX
Testis	37 NX
Placenta	27 NX
Heart muscle	26 NX
Skin	25 NX
Prostate	20 NX
Lung	20 NX
Pancreas	14 NX

Enterocytes	32 NX
Colon	36 NX
Rectum	34 NX
Small intestine	23 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	13 NX
Pancreas	13 NX

Extravillous trophoblasts	35 NX
Placenta	35 NX

Fibroblasts	36 NX
Skin	39 NX
Placenta	30 NX
Prostate	24 NX
Heart muscle	22 NX
Lung	20 NX

Glandular cells	30 NX
Prostate	30 NX

Granulocytes	23 NX
Colon	37 NX
Lung	9 NX

Hepatocytes	28 NX
Liver	28 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	67 NX
Eye	67 NX

Intestinal endocrine cells	43 NX
Rectum	45 NX
Colon	41 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	22 NX
Testis	26 NX
Kidney	24 NX
Skin	23 NX
Pancreas	21 NX
Lung	21 NX
Prostate	14 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	27 NX
Rectum	28 NX
Colon	27 NX
Small intestine	17 NX

Muller glia cells	77 NX
Eye	77 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	26 NX
Colon	35 NX
Rectum	26 NX
Small intestine	21 NX

Peritubular cells	46 NX
Testis	46 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	55 NX
Eye	55 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	26 NX
Heart muscle	30 NX
Skin	28 NX
Prostate	26 NX
Pancreas	25 NX

Spermatocytes	51 NX
Testis	51 NX

Spermatogonia	75 NX
Testis	75 NX

Suprabasal keratinocytes	15 NX
Skin	15 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	40 NX
Colon	51 NX
Liver	50 NX
Kidney	38 NX
Skin	29 NX
Prostate	18 NX
Lung	10 NX

Undifferentiated cells	26 NX
Small intestine	27 NX
Rectum	26 NX
Colon	24 NX

Urothelial cells	28 NX
Prostate	28 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.