Cell type atlas - ACLY - The Human Protein Atlas

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ACLY

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACLY
Gene descriptionⁱ Full gene name according to HGNC.	ATP citrate lyase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	19 NX
Kidney	22 NX
Colon	15 NX
Liver	11 NX

Basal glandular cells	8 NX
Prostate	8 NX

Basal keratinocytes	22 NX
Skin	22 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	16 NX
Lung	16 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	20 NX
Placenta	20 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	66 NX
Testis	66 NX

Endothelial cells	29 NX
Liver	54 NX
Placenta	43 NX
Skin	36 NX
Heart muscle	33 NX
Pancreas	29 NX
Testis	28 NX
Lung	23 NX
Prostate	23 NX
Eye	17 NX

Enterocytes	23 NX
Small intestine	36 NX
Rectum	30 NX
Colon	18 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	30 NX
Pancreas	30 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	30 NX
Placenta	41 NX
Skin	31 NX
Heart muscle	26 NX
Lung	25 NX
Prostate	15 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	14 NX
Lung	28 NX
Colon	0 NX

Hepatocytes	25 NX
Liver	25 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	63 NX
Rectum	66 NX
Colon	61 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	57 NX
Testis	57 NX

Macrophages	22 NX
Kidney	28 NX
Lung	25 NX
Testis	23 NX
Skin	22 NX
Prostate	17 NX
Pancreas	14 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	32 NX
Pancreas	32 NX

Mucus-secreting cells	47 NX
Rectum	57 NX
Colon	52 NX
Small intestine	40 NX

Muller glia cells	7 NX
Eye	7 NX

Pancreatic endocrine cells	34 NX
Pancreas	34 NX

Paneth cells	17 NX
Rectum	23 NX
Colon	17 NX
Small intestine	4 NX

Peritubular cells	48 NX
Testis	48 NX

Proximal tubular cells	71 NX
Kidney	71 NX

Rod photoreceptor cells	7 NX
Eye	6 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	17 NX
Pancreas	64 NX
Prostate	19 NX
Skin	16 NX
Heart muscle	11 NX

Spermatocytes	21 NX
Testis	21 NX

Spermatogonia	34 NX
Testis	34 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	19 NX
Placenta	19 NX

T-cells	21 NX
Liver	23 NX
Skin	22 NX
Kidney	22 NX
Lung	20 NX
Colon	19 NX
Prostate	4 NX

Undifferentiated cells	20 NX
Rectum	23 NX
Colon	17 NX
Small intestine	16 NX

Urothelial cells	12 NX
Prostate	12 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.