Cell type atlas - PPT1 - The Human Protein Atlas

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PPT1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPT1
Gene descriptionⁱ Full gene name according to HGNC.	Palmitoyl-protein thioesterase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Macrophages, Hofbauer cells, Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (SK-BR-3, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Macrophages, Hofbauer cells, Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	35 NX
Colon	45 NX
Liver	35 NX
Kidney	9 NX

Basal glandular cells	72 NX
Prostate	72 NX

Basal keratinocytes	35 NX
Skin	35 NX

Bipolar cells	45 NX
Eye	45 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	48 NX
Lung	48 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	49 NX
Placenta	49 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	52 NX
Pancreas	52 NX

Early spermatids	41 NX
Testis	41 NX

Endothelial cells	45 NX
Pancreas	72 NX
Placenta	64 NX
Eye	58 NX
Skin	48 NX
Liver	45 NX
Testis	43 NX
Heart muscle	42 NX
Lung	35 NX
Prostate	32 NX

Enterocytes	3 NX
Rectum	4 NX
Small intestine	3 NX
Colon	2 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	46 NX
Placenta	55 NX
Heart muscle	51 NX
Skin	46 NX
Prostate	36 NX
Lung	32 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	82 NX
Lung	91 NX
Colon	74 NX

Hepatocytes	8 NX
Liver	8 NX

Hofbauer cells	247 NX
Placenta	247 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	19 NX
Rectum	28 NX
Colon	10 NX

Ito cells	49 NX
Liver	49 NX

Kupffer cells	247 NX
Liver	247 NX

Late spermatids	54 NX
Testis	54 NX

Leydig cells	29 NX
Testis	29 NX

Macrophages	283 NX
Pancreas	419 NX
Skin	342 NX
Prostate	312 NX
Kidney	283 NX
Testis	218 NX
Lung	210 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	155 NX
Pancreas	155 NX

Mucus-secreting cells	8 NX
Rectum	11 NX
Small intestine	5 NX
Colon	4 NX

Muller glia cells	109 NX
Eye	109 NX

Pancreatic endocrine cells	23 NX
Pancreas	23 NX

Paneth cells	7 NX
Rectum	9 NX
Small intestine	7 NX
Colon	0 NX

Peritubular cells	37 NX
Testis	37 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	53 NX
Pancreas	65 NX
Skin	60 NX
Prostate	50 NX
Heart muscle	39 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	38 NX
Testis	38 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	34 NX
Placenta	34 NX

T-cells	41 NX
Lung	65 NX
Kidney	57 NX
Prostate	48 NX
Skin	41 NX
Colon	37 NX
Liver	33 NX

Undifferentiated cells	10 NX
Rectum	12 NX
Small intestine	10 NX
Colon	9 NX

Urothelial cells	29 NX
Prostate	29 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.