Cell type atlas - CAP1 - The Human Protein Atlas

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CAP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CAP1
Gene descriptionⁱ Full gene name according to HGNC.	Cyclase associated actin cytoskeleton regulatory protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	16

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	113 NX
Lung	113 NX

Alveolar cells type 2	90 NX
Lung	90 NX

B-cells	165 NX
Kidney	169 NX
Colon	163 NX
Liver	140 NX

Basal glandular cells	126 NX
Prostate	126 NX

Basal keratinocytes	100 NX
Skin	100 NX

Bipolar cells	40 NX
Eye	40 NX

Cardiomyocytes	14 NX
Heart muscle	14 NX

Cholangiocytes	87 NX
Liver	87 NX

Ciliated cells	74 NX
Lung	74 NX

Club cells	79 NX
Lung	79 NX

Collecting duct cells	108 NX
Kidney	108 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	180 NX
Placenta	180 NX

Distal tubular cells	95 NX
Kidney	95 NX

Ductal cells	336 NX
Pancreas	336 NX

Early spermatids	423 NX
Testis	423 NX

Endothelial cells	137 NX
Pancreas	347 NX
Placenta	184 NX
Testis	176 NX
Eye	170 NX
Skin	137 NX
Lung	137 NX
Prostate	134 NX
Liver	119 NX
Heart muscle	80 NX

Enterocytes	168 NX
Rectum	346 NX
Colon	289 NX
Small intestine	139 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	240 NX
Pancreas	240 NX

Extravillous trophoblasts	381 NX
Placenta	381 NX

Fibroblasts	126 NX
Placenta	148 NX
Skin	122 NX
Lung	108 NX
Prostate	81 NX
Heart muscle	66 NX

Glandular cells	106 NX
Prostate	106 NX

Granulocytes	220 NX
Lung	274 NX
Colon	165 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	384 NX
Placenta	384 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	73 NX
Rectum	75 NX
Colon	71 NX

Ito cells	171 NX
Liver	171 NX

Kupffer cells	377 NX
Liver	377 NX

Late spermatids	351 NX
Testis	351 NX

Leydig cells	81 NX
Testis	81 NX

Macrophages	396 NX
Pancreas	512 NX
Testis	452 NX
Kidney	425 NX
Lung	393 NX
Skin	334 NX
Prostate	287 NX

Melanocytes	95 NX
Skin	95 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	635 NX
Pancreas	635 NX

Mucus-secreting cells	120 NX
Colon	220 NX
Rectum	126 NX
Small intestine	110 NX

Muller glia cells	148 NX
Eye	148 NX

Pancreatic endocrine cells	545 NX
Pancreas	545 NX

Paneth cells	151 NX
Colon	279 NX
Rectum	151 NX
Small intestine	112 NX

Peritubular cells	166 NX
Testis	166 NX

Proximal tubular cells	106 NX
Kidney	106 NX

Rod photoreceptor cells	41 NX
Eye	41 NX

Sertoli cells	162 NX
Testis	162 NX

Smooth muscle cells	157 NX
Pancreas	637 NX
Prostate	157 NX
Skin	151 NX
Heart muscle	115 NX

Spermatocytes	126 NX
Testis	126 NX

Spermatogonia	46 NX
Testis	46 NX

Suprabasal keratinocytes	116 NX
Skin	116 NX

Syncytiotrophoblasts	199 NX
Placenta	199 NX

T-cells	233 NX
Kidney	313 NX
Skin	312 NX
Lung	233 NX
Liver	227 NX
Colon	181 NX
Prostate	122 NX

Undifferentiated cells	111 NX
Colon	183 NX
Rectum	111 NX
Small intestine	101 NX

Urothelial cells	183 NX
Prostate	183 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.