Cell type atlas - BST2 - The Human Protein Atlas

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BST2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BST2
Gene descriptionⁱ Full gene name according to HGNC.	Bone marrow stromal cell antigen 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, Ito cells, Hofbauer cells, Leydig cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, Ito cells, Hofbauer cells, Leydig cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	17 NX
Lung	17 NX

B-cells	81 NX
Liver	115 NX
Colon	106 NX
Kidney	54 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	7 NX
Placenta	7 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	20 NX
Pancreas	20 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	240 NX
Placenta	886 NX
Testis	538 NX
Liver	497 NX
Eye	287 NX
Prostate	234 NX
Heart muscle	218 NX
Skin	137 NX
Lung	105 NX
Pancreas	57 NX

Enterocytes	2 NX
Small intestine	4 NX
Colon	1 NX
Rectum	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	1 NX
Pancreas	1 NX

Extravillous trophoblasts	56 NX
Placenta	56 NX

Fibroblasts	84 NX
Prostate	164 NX
Placenta	120 NX
Skin	113 NX
Heart muscle	25 NX
Lung	19 NX

Glandular cells	7 NX
Prostate	7 NX

Granulocytes	226 NX
Colon	303 NX
Lung	149 NX

Hepatocytes	156 NX
Liver	156 NX

Hofbauer cells	339 NX
Placenta	339 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	1 NX
Rectum	2 NX
Colon	0 NX

Ito cells	362 NX
Liver	362 NX

Kupffer cells	154 NX
Liver	154 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	321 NX
Testis	321 NX

Macrophages	191 NX
Prostate	242 NX
Kidney	242 NX
Testis	220 NX
Skin	191 NX
Pancreas	119 NX
Lung	111 NX

Melanocytes	71 NX
Skin	71 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	239 NX
Pancreas	239 NX

Mucus-secreting cells	1 NX
Small intestine	6 NX
Colon	1 NX
Rectum	0 NX

Muller glia cells	1 NX
Eye	1 NX

Pancreatic endocrine cells	2 NX
Pancreas	2 NX

Paneth cells	4 NX
Colon	9 NX
Small intestine	4 NX
Rectum	1 NX

Peritubular cells	394 NX
Testis	394 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	2 NX
Eye	2 NX

Sertoli cells	162 NX
Testis	162 NX

Smooth muscle cells	150 NX
Skin	193 NX
Prostate	150 NX
Pancreas	72 NX
Heart muscle	56 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	23 NX
Skin	23 NX

Syncytiotrophoblasts	11 NX
Placenta	11 NX

T-cells	127 NX
Prostate	292 NX
Liver	136 NX
Skin	130 NX
Colon	123 NX
Kidney	115 NX
Lung	75 NX

Undifferentiated cells	3 NX
Colon	10 NX
Small intestine	6 NX
Rectum	1 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.