Cell type atlas - SAT1 - The Human Protein Atlas

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SAT1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SAT1
Gene descriptionⁱ Full gene name according to HGNC.	Spermidine/spermine N1-acetyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HBEC3-KT, hTERT-HME1, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	682 NX
Lung	682 NX

Alveolar cells type 2	1578 NX
Lung	1578 NX

B-cells	669 NX
Colon	787 NX
Liver	599 NX
Kidney	575 NX

Basal glandular cells	3442 NX
Prostate	3442 NX

Basal keratinocytes	2163 NX
Skin	2163 NX

Bipolar cells	55 NX
Eye	55 NX

Cardiomyocytes	354 NX
Heart muscle	354 NX

Cholangiocytes	471 NX
Liver	471 NX

Ciliated cells	1633 NX
Lung	1633 NX

Club cells	1773 NX
Lung	1773 NX

Collecting duct cells	787 NX
Kidney	787 NX

Cone photoreceptor cells	110 NX
Eye	110 NX

Cytotrophoblasts	750 NX
Placenta	750 NX

Distal tubular cells	1008 NX
Kidney	1008 NX

Ductal cells	3728 NX
Pancreas	3728 NX

Early spermatids	14 NX
Testis	14 NX

Endothelial cells	552 NX
Prostate	5584 NX
Skin	4196 NX
Eye	1347 NX
Testis	1287 NX
Placenta	552 NX
Lung	519 NX
Pancreas	487 NX
Heart muscle	290 NX
Liver	272 NX

Enterocytes	1333 NX
Small intestine	1604 NX
Colon	1090 NX
Rectum	996 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	2669 NX
Pancreas	2669 NX

Extravillous trophoblasts	834 NX
Placenta	834 NX

Fibroblasts	893 NX
Prostate	6165 NX
Lung	1386 NX
Skin	964 NX
Heart muscle	569 NX
Placenta	166 NX

Glandular cells	4815 NX
Prostate	4815 NX

Granulocytes	834 NX
Lung	1063 NX
Colon	606 NX

Hepatocytes	777 NX
Liver	777 NX

Hofbauer cells	2013 NX
Placenta	2013 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	506 NX
Rectum	564 NX
Colon	449 NX

Ito cells	417 NX
Liver	417 NX

Kupffer cells	3441 NX
Liver	3441 NX

Late spermatids	25 NX
Testis	25 NX

Leydig cells	153 NX
Testis	153 NX

Macrophages	4222 NX
Prostate	18527 NX
Skin	7780 NX
Kidney	4804 NX
Testis	3641 NX
Lung	2959 NX
Pancreas	1568 NX

Melanocytes	3720 NX
Skin	3720 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	7875 NX
Pancreas	7875 NX

Mucus-secreting cells	746 NX
Colon	993 NX
Small intestine	787 NX
Rectum	500 NX

Muller glia cells	528 NX
Eye	528 NX

Pancreatic endocrine cells	2966 NX
Pancreas	2966 NX

Paneth cells	1221 NX
Colon	1514 NX
Small intestine	1221 NX
Rectum	763 NX

Peritubular cells	87 NX
Testis	87 NX

Proximal tubular cells	1311 NX
Kidney	1311 NX

Rod photoreceptor cells	93 NX
Eye	93 NX

Sertoli cells	149 NX
Testis	149 NX

Smooth muscle cells	597 NX
Prostate	2234 NX
Skin	926 NX
Pancreas	449 NX
Heart muscle	338 NX

Spermatocytes	9 NX
Testis	9 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	1284 NX
Skin	1284 NX

Syncytiotrophoblasts	2409 NX
Placenta	2409 NX

T-cells	468 NX
Prostate	5557 NX
Skin	1103 NX
Lung	775 NX
Kidney	599 NX
Colon	468 NX
Liver	254 NX

Undifferentiated cells	552 NX
Colon	950 NX
Rectum	552 NX
Small intestine	525 NX

Urothelial cells	4788 NX
Prostate	4788 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.