Cell type atlas - REEP5 - The Human Protein Atlas

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REEP5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	REEP5
Gene descriptionⁱ Full gene name according to HGNC.	Receptor accessory protein 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	155 NX
Lung	155 NX

Alveolar cells type 2	82 NX
Lung	82 NX

B-cells	97 NX
Liver	150 NX
Kidney	103 NX
Colon	91 NX

Basal glandular cells	144 NX
Prostate	144 NX

Basal keratinocytes	83 NX
Skin	83 NX

Bipolar cells	82 NX
Eye	82 NX

Cardiomyocytes	185 NX
Heart muscle	185 NX

Cholangiocytes	125 NX
Liver	125 NX

Ciliated cells	96 NX
Lung	96 NX

Club cells	99 NX
Lung	99 NX

Collecting duct cells	185 NX
Kidney	185 NX

Cone photoreceptor cells	84 NX
Eye	84 NX

Cytotrophoblasts	246 NX
Placenta	246 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	244 NX
Pancreas	244 NX

Early spermatids	114 NX
Testis	114 NX

Endothelial cells	119 NX
Pancreas	229 NX
Placenta	162 NX
Heart muscle	140 NX
Prostate	127 NX
Liver	115 NX
Eye	109 NX
Skin	104 NX
Testis	101 NX
Lung	88 NX

Enterocytes	82 NX
Small intestine	116 NX
Rectum	71 NX
Colon	70 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	361 NX
Pancreas	361 NX

Extravillous trophoblasts	269 NX
Placenta	269 NX

Fibroblasts	176 NX
Prostate	355 NX
Skin	190 NX
Placenta	189 NX
Heart muscle	137 NX
Lung	74 NX

Glandular cells	190 NX
Prostate	190 NX

Granulocytes	105 NX
Lung	119 NX
Colon	92 NX

Hepatocytes	181 NX
Liver	181 NX

Hofbauer cells	246 NX
Placenta	246 NX

Horizontal cells	83 NX
Eye	83 NX

Intestinal endocrine cells	113 NX
Colon	119 NX
Rectum	108 NX

Ito cells	107 NX
Liver	107 NX

Kupffer cells	125 NX
Liver	125 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	108 NX
Testis	108 NX

Macrophages	190 NX
Pancreas	393 NX
Kidney	201 NX
Testis	191 NX
Lung	185 NX
Skin	164 NX
Prostate	122 NX

Melanocytes	196 NX
Skin	196 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	116 NX
Pancreas	116 NX

Mucus-secreting cells	94 NX
Colon	162 NX
Small intestine	96 NX
Rectum	79 NX

Muller glia cells	87 NX
Eye	87 NX

Pancreatic endocrine cells	283 NX
Pancreas	282 NX

Paneth cells	138 NX
Small intestine	140 NX
Colon	138 NX
Rectum	104 NX

Peritubular cells	126 NX
Testis	126 NX

Proximal tubular cells	117 NX
Kidney	117 NX

Rod photoreceptor cells	67 NX
Eye	67 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	132 NX
Pancreas	261 NX
Prostate	149 NX
Heart muscle	132 NX
Skin	109 NX

Spermatocytes	117 NX
Testis	117 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	89 NX
Skin	89 NX

Syncytiotrophoblasts	410 NX
Placenta	410 NX

T-cells	105 NX
Skin	144 NX
Kidney	122 NX
Colon	115 NX
Lung	109 NX
Prostate	105 NX
Liver	83 NX

Undifferentiated cells	92 NX
Colon	126 NX
Rectum	92 NX
Small intestine	65 NX

Urothelial cells	181 NX
Prostate	181 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.