Cell type atlas - DAD1 - The Human Protein Atlas

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DAD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DAD1
Gene descriptionⁱ Full gene name according to HGNC.	Defender against cell death 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	149 NX
Lung	149 NX

Alveolar cells type 2	165 NX
Lung	165 NX

B-cells	143 NX
Liver	229 NX
Kidney	183 NX
Colon	103 NX

Basal glandular cells	161 NX
Prostate	161 NX

Basal keratinocytes	176 NX
Skin	176 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	137 NX
Heart muscle	137 NX

Cholangiocytes	171 NX
Liver	171 NX

Ciliated cells	220 NX
Lung	220 NX

Club cells	109 NX
Lung	109 NX

Collecting duct cells	243 NX
Kidney	243 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	222 NX
Placenta	222 NX

Distal tubular cells	182 NX
Kidney	182 NX

Ductal cells	459 NX
Pancreas	459 NX

Early spermatids	136 NX
Testis	136 NX

Endothelial cells	238 NX
Pancreas	373 NX
Placenta	373 NX
Skin	318 NX
Heart muscle	289 NX
Testis	238 NX
Prostate	223 NX
Liver	173 NX
Lung	166 NX
Eye	147 NX

Enterocytes	169 NX
Small intestine	217 NX
Rectum	138 NX
Colon	133 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	363 NX
Pancreas	363 NX

Extravillous trophoblasts	310 NX
Placenta	310 NX

Fibroblasts	254 NX
Heart muscle	348 NX
Skin	271 NX
Placenta	269 NX
Prostate	183 NX
Lung	148 NX

Glandular cells	161 NX
Prostate	161 NX

Granulocytes	293 NX
Lung	328 NX
Colon	257 NX

Hepatocytes	227 NX
Liver	227 NX

Hofbauer cells	313 NX
Placenta	313 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	130 NX
Rectum	152 NX
Colon	109 NX

Ito cells	183 NX
Liver	183 NX

Kupffer cells	141 NX
Liver	141 NX

Late spermatids	71 NX
Testis	71 NX

Leydig cells	199 NX
Testis	199 NX

Macrophages	173 NX
Pancreas	342 NX
Kidney	228 NX
Skin	214 NX
Testis	148 NX
Lung	135 NX
Prostate	132 NX

Melanocytes	314 NX
Skin	314 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	230 NX
Pancreas	230 NX

Mucus-secreting cells	163 NX
Colon	326 NX
Small intestine	174 NX
Rectum	124 NX

Muller glia cells	174 NX
Eye	174 NX

Pancreatic endocrine cells	363 NX
Pancreas	363 NX

Paneth cells	132 NX
Colon	173 NX
Rectum	132 NX
Small intestine	130 NX

Peritubular cells	187 NX
Testis	187 NX

Proximal tubular cells	354 NX
Kidney	354 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	149 NX
Testis	149 NX

Smooth muscle cells	196 NX
Pancreas	615 NX
Heart muscle	309 NX
Skin	169 NX
Prostate	130 NX

Spermatocytes	167 NX
Testis	167 NX

Spermatogonia	132 NX
Testis	132 NX

Suprabasal keratinocytes	189 NX
Skin	189 NX

Syncytiotrophoblasts	242 NX
Placenta	242 NX

T-cells	164 NX
Kidney	346 NX
Skin	270 NX
Prostate	222 NX
Lung	204 NX
Colon	164 NX
Liver	97 NX

Undifferentiated cells	144 NX
Colon	213 NX
Small intestine	144 NX
Rectum	139 NX

Urothelial cells	148 NX
Prostate	148 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.