Cell type atlas - MPDU1 - The Human Protein Atlas

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MPDU1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPDU1
Gene descriptionⁱ Full gene name according to HGNC.	Mannose-P-dolichol utilization defect 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	42 NX
Colon	60 NX
Liver	42 NX
Kidney	13 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	10 NX
Skin	10 NX

Bipolar cells	16 NX
Eye	15 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	99 NX
Placenta	99 NX

Distal tubular cells	30 NX
Kidney	30 NX

Ductal cells	57 NX
Pancreas	57 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	16 NX
Placenta	62 NX
Pancreas	36 NX
Prostate	35 NX
Testis	22 NX
Eye	20 NX
Skin	16 NX
Lung	12 NX
Liver	7 NX
Heart muscle	5 NX

Enterocytes	81 NX
Colon	120 NX
Small intestine	68 NX
Rectum	60 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	67 NX
Pancreas	67 NX

Extravillous trophoblasts	78 NX
Placenta	78 NX

Fibroblasts	25 NX
Placenta	53 NX
Lung	26 NX
Prostate	15 NX
Skin	15 NX
Heart muscle	3 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	70 NX
Placenta	70 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	36 NX
Rectum	37 NX
Colon	34 NX

Ito cells	27 NX
Liver	27 NX

Kupffer cells	32 NX
Liver	32 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	35 NX
Pancreas	105 NX
Prostate	53 NX
Kidney	50 NX
Lung	28 NX
Skin	27 NX
Testis	26 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	40 NX
Pancreas	40 NX

Mucus-secreting cells	56 NX
Colon	81 NX
Small intestine	62 NX
Rectum	38 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	60 NX
Pancreas	60 NX

Paneth cells	67 NX
Colon	95 NX
Small intestine	67 NX
Rectum	46 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	11 NX
Pancreas	75 NX
Prostate	16 NX
Skin	9 NX
Heart muscle	1 NX

Spermatocytes	20 NX
Testis	20 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	11 NX
Skin	11 NX

Syncytiotrophoblasts	132 NX
Placenta	132 NX

T-cells	22 NX
Lung	46 NX
Colon	43 NX
Kidney	31 NX
Prostate	22 NX
Liver	20 NX
Skin	11 NX

Undifferentiated cells	54 NX
Colon	90 NX
Small intestine	58 NX
Rectum	43 NX

Urothelial cells	36 NX
Prostate	36 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.