Cell type atlas - HAT1 - The Human Protein Atlas

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HAT1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HAT1
Gene descriptionⁱ Full gene name according to HGNC.	Histone acetyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	45 NX
Kidney	58 NX
Colon	42 NX
Liver	24 NX

Basal glandular cells	101 NX
Prostate	101 NX

Basal keratinocytes	66 NX
Skin	66 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	47 NX
Heart muscle	47 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	46 NX
Lung	46 NX

Club cells	31 NX
Lung	31 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	65 NX
Placenta	65 NX

Distal tubular cells	70 NX
Kidney	70 NX

Ductal cells	36 NX
Pancreas	36 NX

Early spermatids	43 NX
Testis	43 NX

Endothelial cells	38 NX
Pancreas	72 NX
Prostate	59 NX
Skin	42 NX
Placenta	42 NX
Lung	38 NX
Heart muscle	33 NX
Testis	32 NX
Eye	30 NX
Liver	16 NX

Enterocytes	16 NX
Small intestine	16 NX
Colon	15 NX
Rectum	14 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	41 NX
Pancreas	41 NX

Extravillous trophoblasts	72 NX
Placenta	72 NX

Fibroblasts	42 NX
Prostate	60 NX
Placenta	58 NX
Skin	39 NX
Lung	36 NX
Heart muscle	23 NX

Glandular cells	50 NX
Prostate	50 NX

Granulocytes	40 NX
Colon	55 NX
Lung	26 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	14 NX
Colon	20 NX
Rectum	7 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	33 NX
Liver	33 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	28 NX
Testis	28 NX

Macrophages	38 NX
Lung	42 NX
Skin	41 NX
Testis	38 NX
Kidney	37 NX
Pancreas	37 NX
Prostate	27 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	19 NX
Pancreas	19 NX

Mucus-secreting cells	18 NX
Small intestine	19 NX
Colon	19 NX
Rectum	17 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	18 NX
Small intestine	25 NX
Rectum	18 NX
Colon	14 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	35 NX
Kidney	35 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	59 NX
Pancreas	60 NX
Prostate	60 NX
Heart muscle	59 NX
Skin	48 NX

Spermatocytes	46 NX
Testis	46 NX

Spermatogonia	64 NX
Testis	64 NX

Suprabasal keratinocytes	46 NX
Skin	46 NX

Syncytiotrophoblasts	49 NX
Placenta	49 NX

T-cells	41 NX
Prostate	78 NX
Skin	54 NX
Kidney	54 NX
Colon	49 NX
Lung	37 NX
Liver	31 NX

Undifferentiated cells	28 NX
Colon	31 NX
Small intestine	29 NX
Rectum	15 NX

Urothelial cells	61 NX
Prostate	61 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.