Cell type atlas - ATP6V1F - The Human Protein Atlas

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ATP6V1F

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP6V1F
Gene descriptionⁱ Full gene name according to HGNC.	ATPase H+ transporting V1 subunit F
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	65 NX
Lung	65 NX

B-cells	166 NX
Colon	246 NX
Liver	132 NX
Kidney	125 NX

Basal glandular cells	164 NX
Prostate	164 NX

Basal keratinocytes	211 NX
Skin	211 NX

Bipolar cells	100 NX
Eye	100 NX

Cardiomyocytes	144 NX
Heart muscle	144 NX

Cholangiocytes	150 NX
Liver	150 NX

Ciliated cells	76 NX
Lung	76 NX

Club cells	53 NX
Lung	53 NX

Collecting duct cells	314 NX
Kidney	314 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	152 NX
Placenta	152 NX

Distal tubular cells	894 NX
Kidney	894 NX

Ductal cells	206 NX
Pancreas	206 NX

Early spermatids	443 NX
Testis	443 NX

Endothelial cells	190 NX
Prostate	321 NX
Skin	238 NX
Placenta	192 NX
Pancreas	190 NX
Testis	162 NX
Liver	162 NX
Heart muscle	150 NX
Eye	127 NX
Lung	35 NX

Enterocytes	97 NX
Small intestine	176 NX
Rectum	88 NX
Colon	79 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	195 NX
Pancreas	195 NX

Extravillous trophoblasts	171 NX
Placenta	171 NX

Fibroblasts	185 NX
Prostate	296 NX
Placenta	205 NX
Skin	175 NX
Heart muscle	100 NX
Lung	66 NX

Glandular cells	189 NX
Prostate	189 NX

Granulocytes	270 NX
Colon	312 NX
Lung	228 NX

Hepatocytes	99 NX
Liver	99 NX

Hofbauer cells	1024 NX
Placenta	1024 NX

Horizontal cells	515 NX
Eye	515 NX

Intestinal endocrine cells	109 NX
Colon	112 NX
Rectum	105 NX

Ito cells	105 NX
Liver	105 NX

Kupffer cells	280 NX
Liver	280 NX

Late spermatids	674 NX
Testis	674 NX

Leydig cells	152 NX
Testis	152 NX

Macrophages	339 NX
Pancreas	1350 NX
Prostate	931 NX
Kidney	599 NX
Testis	299 NX
Skin	286 NX
Lung	235 NX

Melanocytes	241 NX
Skin	241 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	250 NX
Pancreas	250 NX

Mucus-secreting cells	88 NX
Colon	117 NX
Rectum	96 NX
Small intestine	79 NX

Muller glia cells	129 NX
Eye	129 NX

Pancreatic endocrine cells	222 NX
Pancreas	222 NX

Paneth cells	83 NX
Colon	95 NX
Rectum	83 NX
Small intestine	74 NX

Peritubular cells	120 NX
Testis	120 NX

Proximal tubular cells	705 NX
Kidney	705 NX

Rod photoreceptor cells	64 NX
Eye	64 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	185 NX
Heart muscle	220 NX
Pancreas	208 NX
Prostate	185 NX
Skin	113 NX

Spermatocytes	202 NX
Testis	202 NX

Spermatogonia	99 NX
Testis	99 NX

Suprabasal keratinocytes	286 NX
Skin	286 NX

Syncytiotrophoblasts	336 NX
Placenta	336 NX

T-cells	137 NX
Kidney	231 NX
Prostate	196 NX
Skin	193 NX
Colon	138 NX
Liver	120 NX
Lung	79 NX

Undifferentiated cells	88 NX
Rectum	94 NX
Colon	88 NX
Small intestine	77 NX

Urothelial cells	298 NX
Prostate	298 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.