Cell type atlas - ATF4 - The Human Protein Atlas

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ATF4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATF4
Gene descriptionⁱ Full gene name according to HGNC.	Activating transcription factor 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	158 NX
Lung	158 NX

Alveolar cells type 2	173 NX
Lung	173 NX

B-cells	189 NX
Colon	279 NX
Liver	217 NX
Kidney	94 NX

Basal glandular cells	330 NX
Prostate	330 NX

Basal keratinocytes	394 NX
Skin	394 NX

Bipolar cells	109 NX
Eye	109 NX

Cardiomyocytes	145 NX
Heart muscle	145 NX

Cholangiocytes	117 NX
Liver	117 NX

Ciliated cells	83 NX
Lung	83 NX

Club cells	147 NX
Lung	147 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	88 NX
Eye	88 NX

Cytotrophoblasts	124 NX
Placenta	124 NX

Distal tubular cells	56 NX
Kidney	56 NX

Ductal cells	170 NX
Pancreas	170 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	187 NX
Prostate	426 NX
Skin	373 NX
Testis	241 NX
Pancreas	218 NX
Liver	187 NX
Eye	165 NX
Heart muscle	163 NX
Placenta	135 NX
Lung	85 NX

Enterocytes	267 NX
Colon	498 NX
Small intestine	220 NX
Rectum	138 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	656 NX
Pancreas	656 NX

Extravillous trophoblasts	206 NX
Placenta	206 NX

Fibroblasts	208 NX
Prostate	345 NX
Skin	274 NX
Lung	208 NX
Placenta	160 NX
Heart muscle	158 NX

Glandular cells	324 NX
Prostate	324 NX

Granulocytes	217 NX
Colon	220 NX
Lung	214 NX

Hepatocytes	158 NX
Liver	158 NX

Hofbauer cells	102 NX
Placenta	102 NX

Horizontal cells	65 NX
Eye	65 NX

Intestinal endocrine cells	256 NX
Colon	350 NX
Rectum	162 NX

Ito cells	130 NX
Liver	130 NX

Kupffer cells	155 NX
Liver	155 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	172 NX
Testis	172 NX

Macrophages	208 NX
Prostate	302 NX
Skin	260 NX
Testis	232 NX
Lung	186 NX
Pancreas	124 NX
Kidney	87 NX

Melanocytes	226 NX
Skin	226 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	297 NX
Pancreas	297 NX

Mucus-secreting cells	194 NX
Colon	595 NX
Small intestine	227 NX
Rectum	167 NX

Muller glia cells	69 NX
Eye	69 NX

Pancreatic endocrine cells	384 NX
Pancreas	384 NX

Paneth cells	163 NX
Colon	582 NX
Rectum	163 NX
Small intestine	151 NX

Peritubular cells	195 NX
Testis	195 NX

Proximal tubular cells	61 NX
Kidney	61 NX

Rod photoreceptor cells	235 NX
Eye	235 NX

Sertoli cells	330 NX
Testis	330 NX

Smooth muscle cells	310 NX
Prostate	567 NX
Skin	385 NX
Pancreas	224 NX
Heart muscle	183 NX

Spermatocytes	70 NX
Testis	70 NX

Spermatogonia	63 NX
Testis	63 NX

Suprabasal keratinocytes	294 NX
Skin	294 NX

Syncytiotrophoblasts	183 NX
Placenta	183 NX

T-cells	142 NX
Prostate	270 NX
Colon	270 NX
Skin	254 NX
Lung	184 NX
Liver	122 NX
Kidney	77 NX

Undifferentiated cells	165 NX
Colon	363 NX
Small intestine	174 NX
Rectum	132 NX

Urothelial cells	347 NX
Prostate	347 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.