Cell type atlas - PTPN12 - The Human Protein Atlas

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PTPN12

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PTPN12
Gene descriptionⁱ Full gene name according to HGNC.	Protein tyrosine phosphatase, non-receptor type 12
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	55 NX
Lung	55 NX

B-cells	14 NX
Liver	15 NX
Colon	13 NX
Kidney	5 NX

Basal glandular cells	42 NX
Prostate	42 NX

Basal keratinocytes	61 NX
Skin	61 NX

Bipolar cells	16 NX
Eye	16 NX

Cardiomyocytes	35 NX
Heart muscle	35 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	47 NX
Lung	47 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	34 NX
Placenta	34 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	39 NX
Pancreas	39 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	99 NX
Prostate	176 NX
Heart muscle	141 NX
Skin	129 NX
Lung	99 NX
Liver	92 NX
Testis	84 NX
Eye	70 NX
Placenta	69 NX
Pancreas	61 NX

Enterocytes	17 NX
Rectum	28 NX
Colon	24 NX
Small intestine	9 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	48 NX
Placenta	48 NX

Fibroblasts	54 NX
Skin	69 NX
Heart muscle	68 NX
Prostate	54 NX
Placenta	33 NX
Lung	32 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	45 NX
Placenta	45 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	12 NX
Rectum	16 NX
Colon	7 NX

Ito cells	99 NX
Liver	99 NX

Kupffer cells	74 NX
Liver	74 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	43 NX
Testis	43 NX

Macrophages	87 NX
Pancreas	112 NX
Lung	111 NX
Skin	87 NX
Kidney	75 NX
Prostate	72 NX
Testis	69 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	20 NX
Rectum	25 NX
Colon	19 NX
Small intestine	15 NX

Muller glia cells	63 NX
Eye	63 NX

Pancreatic endocrine cells	55 NX
Pancreas	55 NX

Paneth cells	20 NX
Rectum	24 NX
Colon	20 NX
Small intestine	14 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	56 NX
Heart muscle	106 NX
Pancreas	65 NX
Prostate	53 NX
Skin	51 NX

Spermatocytes	15 NX
Testis	15 NX

Spermatogonia	58 NX
Testis	58 NX

Suprabasal keratinocytes	89 NX
Skin	89 NX

Syncytiotrophoblasts	60 NX
Placenta	60 NX

T-cells	26 NX
Liver	103 NX
Lung	55 NX
Kidney	26 NX
Prostate	18 NX
Colon	18 NX
Skin	17 NX

Undifferentiated cells	18 NX
Colon	29 NX
Rectum	19 NX
Small intestine	15 NX

Urothelial cells	79 NX
Prostate	79 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.