Cell type atlas - ECHS1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ECHS1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ECHS1
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA hydratase, short chain 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	72 NX
Lung	72 NX

B-cells	78 NX
Kidney	116 NX
Colon	61 NX
Liver	48 NX

Basal glandular cells	80 NX
Prostate	80 NX

Basal keratinocytes	61 NX
Skin	61 NX

Bipolar cells	59 NX
Eye	59 NX

Cardiomyocytes	224 NX
Heart muscle	224 NX

Cholangiocytes	181 NX
Liver	181 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	166 NX
Kidney	166 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	407 NX
Placenta	407 NX

Distal tubular cells	479 NX
Kidney	479 NX

Ductal cells	144 NX
Pancreas	144 NX

Early spermatids	24 NX
Testis	24 NX

Endothelial cells	65 NX
Placenta	103 NX
Heart muscle	77 NX
Pancreas	75 NX
Eye	71 NX
Skin	65 NX
Liver	63 NX
Testis	61 NX
Lung	55 NX
Prostate	37 NX

Enterocytes	374 NX
Small intestine	407 NX
Colon	273 NX
Rectum	154 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	89 NX
Pancreas	88 NX

Extravillous trophoblasts	127 NX
Placenta	127 NX

Fibroblasts	75 NX
Placenta	138 NX
Heart muscle	113 NX
Lung	74 NX
Skin	69 NX
Prostate	54 NX

Glandular cells	84 NX
Prostate	84 NX

Granulocytes	89 NX
Colon	92 NX
Lung	86 NX

Hepatocytes	1339 NX
Liver	1339 NX

Hofbauer cells	194 NX
Placenta	194 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	126 NX
Colon	143 NX
Rectum	110 NX

Ito cells	79 NX
Liver	79 NX

Kupffer cells	89 NX
Liver	89 NX

Late spermatids	30 NX
Testis	30 NX

Leydig cells	72 NX
Testis	72 NX

Macrophages	73 NX
Kidney	238 NX
Pancreas	155 NX
Lung	69 NX
Prostate	68 NX
Skin	65 NX
Testis	57 NX

Melanocytes	128 NX
Skin	128 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	150 NX
Pancreas	150 NX

Mucus-secreting cells	153 NX
Colon	282 NX
Small intestine	156 NX
Rectum	138 NX

Muller glia cells	113 NX
Eye	113 NX

Pancreatic endocrine cells	100 NX
Pancreas	100 NX

Paneth cells	253 NX
Colon	253 NX
Small intestine	253 NX
Rectum	168 NX

Peritubular cells	86 NX
Testis	86 NX

Proximal tubular cells	2022 NX
Kidney	2022 NX

Rod photoreceptor cells	42 NX
Eye	42 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	77 NX
Pancreas	161 NX
Heart muscle	103 NX
Skin	72 NX
Prostate	58 NX

Spermatocytes	51 NX
Testis	51 NX

Spermatogonia	40 NX
Testis	40 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	250 NX
Placenta	250 NX

T-cells	49 NX
Kidney	172 NX
Colon	65 NX
Skin	60 NX
Lung	49 NX
Liver	49 NX
Prostate	44 NX

Undifferentiated cells	277 NX
Colon	359 NX
Small intestine	278 NX
Rectum	204 NX

Urothelial cells	104 NX
Prostate	104 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.