Cell type atlas - MACF1 - The Human Protein Atlas

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MACF1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MACF1
Gene descriptionⁱ Full gene name according to HGNC.	Microtubule-actin crosslinking factor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells, Rod photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells, Rod photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	140 NX
Lung	140 NX

Alveolar cells type 2	115 NX
Lung	115 NX

B-cells	34 NX
Colon	61 NX
Kidney	45 NX
Liver	19 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	137 NX
Skin	137 NX

Bipolar cells	377 NX
Eye	377 NX

Cardiomyocytes	223 NX
Heart muscle	223 NX

Cholangiocytes	77 NX
Liver	77 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	85 NX
Lung	85 NX

Collecting duct cells	77 NX
Kidney	77 NX

Cone photoreceptor cells	734 NX
Eye	734 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	105 NX
Pancreas	105 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	147 NX
Heart muscle	221 NX
Lung	198 NX
Eye	189 NX
Prostate	153 NX
Pancreas	147 NX
Liver	108 NX
Testis	104 NX
Skin	103 NX
Placenta	87 NX

Enterocytes	22 NX
Rectum	32 NX
Colon	26 NX
Small intestine	19 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	98 NX
Pancreas	98 NX

Extravillous trophoblasts	50 NX
Placenta	50 NX

Fibroblasts	58 NX
Lung	194 NX
Heart muscle	152 NX
Prostate	97 NX
Skin	59 NX
Placenta	45 NX

Glandular cells	60 NX
Prostate	60 NX

Granulocytes	73 NX
Lung	119 NX
Colon	28 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	44 NX
Placenta	44 NX

Horizontal cells	111 NX
Eye	111 NX

Intestinal endocrine cells	35 NX
Rectum	42 NX
Colon	27 NX

Ito cells	127 NX
Liver	127 NX

Kupffer cells	56 NX
Liver	56 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	42 NX
Lung	72 NX
Prostate	58 NX
Testis	40 NX
Kidney	39 NX
Skin	35 NX
Pancreas	33 NX

Melanocytes	67 NX
Skin	67 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	45 NX
Pancreas	45 NX

Mucus-secreting cells	24 NX
Rectum	26 NX
Small intestine	25 NX
Colon	22 NX

Muller glia cells	104 NX
Eye	104 NX

Pancreatic endocrine cells	136 NX
Pancreas	136 NX

Paneth cells	17 NX
Colon	20 NX
Rectum	17 NX
Small intestine	11 NX

Peritubular cells	106 NX
Testis	106 NX

Proximal tubular cells	8 NX
Kidney	8 NX

Rod photoreceptor cells	426 NX
Eye	425 NX

Sertoli cells	104 NX
Testis	104 NX

Smooth muscle cells	70 NX
Heart muscle	225 NX
Prostate	101 NX
Skin	63 NX
Pancreas	49 NX

Spermatocytes	34 NX
Testis	34 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	167 NX
Skin	167 NX

Syncytiotrophoblasts	59 NX
Placenta	59 NX

T-cells	78 NX
Lung	141 NX
Liver	94 NX
Skin	78 NX
Colon	75 NX
Kidney	73 NX
Prostate	26 NX

Undifferentiated cells	18 NX
Rectum	19 NX
Small intestine	18 NX
Colon	9 NX

Urothelial cells	61 NX
Prostate	61 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.