Cell type atlas - HP1BP3 - The Human Protein Atlas

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HP1BP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HP1BP3
Gene descriptionⁱ Full gene name according to HGNC.	Heterochromatin protein 1 binding protein 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	140 NX
Lung	140 NX

Alveolar cells type 2	128 NX
Lung	128 NX

B-cells	86 NX
Liver	102 NX
Kidney	80 NX
Colon	79 NX

Basal glandular cells	101 NX
Prostate	101 NX

Basal keratinocytes	116 NX
Skin	116 NX

Bipolar cells	110 NX
Eye	110 NX

Cardiomyocytes	129 NX
Heart muscle	129 NX

Cholangiocytes	97 NX
Liver	97 NX

Ciliated cells	72 NX
Lung	72 NX

Club cells	125 NX
Lung	125 NX

Collecting duct cells	100 NX
Kidney	100 NX

Cone photoreceptor cells	51 NX
Eye	51 NX

Cytotrophoblasts	71 NX
Placenta	71 NX

Distal tubular cells	131 NX
Kidney	131 NX

Ductal cells	74 NX
Pancreas	74 NX

Early spermatids	29 NX
Testis	29 NX

Endothelial cells	135 NX
Heart muscle	281 NX
Lung	152 NX
Testis	142 NX
Liver	135 NX
Skin	125 NX
Prostate	94 NX
Eye	92 NX
Placenta	80 NX
Pancreas	72 NX

Enterocytes	82 NX
Colon	83 NX
Rectum	81 NX
Small intestine	78 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	81 NX
Pancreas	81 NX

Extravillous trophoblasts	56 NX
Placenta	56 NX

Fibroblasts	121 NX
Heart muscle	210 NX
Lung	198 NX
Skin	132 NX
Prostate	121 NX
Placenta	64 NX

Glandular cells	106 NX
Prostate	106 NX

Granulocytes	130 NX
Lung	205 NX
Colon	55 NX

Hepatocytes	90 NX
Liver	90 NX

Hofbauer cells	63 NX
Placenta	63 NX

Horizontal cells	76 NX
Eye	76 NX

Intestinal endocrine cells	100 NX
Rectum	101 NX
Colon	99 NX

Ito cells	116 NX
Liver	116 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	160 NX
Testis	160 NX

Macrophages	90 NX
Lung	165 NX
Testis	109 NX
Skin	83 NX
Kidney	83 NX
Prostate	77 NX
Pancreas	66 NX

Melanocytes	108 NX
Skin	108 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	91 NX
Pancreas	91 NX

Mucus-secreting cells	99 NX
Colon	120 NX
Rectum	101 NX
Small intestine	75 NX

Muller glia cells	111 NX
Eye	111 NX

Pancreatic endocrine cells	89 NX
Pancreas	89 NX

Paneth cells	85 NX
Colon	89 NX
Rectum	85 NX
Small intestine	70 NX

Peritubular cells	153 NX
Testis	153 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	93 NX
Eye	93 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	105 NX
Heart muscle	298 NX
Prostate	105 NX
Skin	97 NX
Pancreas	64 NX

Spermatocytes	111 NX
Testis	111 NX

Spermatogonia	94 NX
Testis	94 NX

Suprabasal keratinocytes	118 NX
Skin	118 NX

Syncytiotrophoblasts	78 NX
Placenta	78 NX

T-cells	103 NX
Lung	226 NX
Colon	126 NX
Kidney	107 NX
Skin	103 NX
Prostate	96 NX
Liver	90 NX

Undifferentiated cells	91 NX
Colon	112 NX
Rectum	91 NX
Small intestine	85 NX

Urothelial cells	95 NX
Prostate	95 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.