Cell type atlas - CANX - The Human Protein Atlas

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CANX

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CANX
Gene descriptionⁱ Full gene name according to HGNC.	Calnexin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	185 NX
Lung	185 NX

Alveolar cells type 2	237 NX
Lung	237 NX

B-cells	94 NX
Liver	193 NX
Kidney	89 NX
Colon	75 NX

Basal glandular cells	89 NX
Prostate	89 NX

Basal keratinocytes	132 NX
Skin	132 NX

Bipolar cells	112 NX
Eye	112 NX

Cardiomyocytes	433 NX
Heart muscle	433 NX

Cholangiocytes	181 NX
Liver	181 NX

Ciliated cells	324 NX
Lung	324 NX

Club cells	284 NX
Lung	284 NX

Collecting duct cells	173 NX
Kidney	173 NX

Cone photoreceptor cells	149 NX
Eye	149 NX

Cytotrophoblasts	139 NX
Placenta	139 NX

Distal tubular cells	41 NX
Kidney	41 NX

Ductal cells	149 NX
Pancreas	149 NX

Early spermatids	198 NX
Testis	198 NX

Endothelial cells	180 NX
Heart muscle	294 NX
Lung	265 NX
Placenta	186 NX
Pancreas	183 NX
Prostate	180 NX
Liver	166 NX
Skin	147 NX
Testis	139 NX
Eye	116 NX

Enterocytes	167 NX
Colon	188 NX
Small intestine	171 NX
Rectum	135 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	132 NX
Pancreas	132 NX

Extravillous trophoblasts	188 NX
Placenta	188 NX

Fibroblasts	146 NX
Lung	368 NX
Heart muscle	243 NX
Prostate	161 NX
Skin	150 NX
Placenta	130 NX

Glandular cells	221 NX
Prostate	221 NX

Granulocytes	189 NX
Lung	258 NX
Colon	119 NX

Hepatocytes	394 NX
Liver	394 NX

Hofbauer cells	206 NX
Placenta	206 NX

Horizontal cells	151 NX
Eye	151 NX

Intestinal endocrine cells	171 NX
Colon	173 NX
Rectum	169 NX

Ito cells	164 NX
Liver	164 NX

Kupffer cells	186 NX
Liver	186 NX

Late spermatids	659 NX
Testis	659 NX

Leydig cells	147 NX
Testis	147 NX

Macrophages	192 NX
Lung	357 NX
Prostate	236 NX
Skin	192 NX
Pancreas	185 NX
Testis	175 NX
Kidney	135 NX

Melanocytes	167 NX
Skin	167 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	121 NX
Pancreas	121 NX

Mucus-secreting cells	180 NX
Colon	337 NX
Rectum	185 NX
Small intestine	124 NX

Muller glia cells	202 NX
Eye	202 NX

Pancreatic endocrine cells	157 NX
Pancreas	157 NX

Paneth cells	98 NX
Rectum	164 NX
Colon	98 NX
Small intestine	77 NX

Peritubular cells	180 NX
Testis	180 NX

Proximal tubular cells	161 NX
Kidney	161 NX

Rod photoreceptor cells	108 NX
Eye	108 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	153 NX
Heart muscle	324 NX
Pancreas	182 NX
Prostate	153 NX
Skin	126 NX

Spermatocytes	141 NX
Testis	141 NX

Spermatogonia	81 NX
Testis	81 NX

Suprabasal keratinocytes	141 NX
Skin	141 NX

Syncytiotrophoblasts	205 NX
Placenta	205 NX

T-cells	89 NX
Lung	154 NX
Skin	107 NX
Colon	94 NX
Kidney	89 NX
Liver	64 NX
Prostate	52 NX

Undifferentiated cells	179 NX
Colon	309 NX
Rectum	184 NX
Small intestine	160 NX

Urothelial cells	132 NX
Prostate	132 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.