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Reliability score mouse brain
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Secretome annotation
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Subcellular location - cell line (ICC)
Subcellular Cell Cycle Peak Phase
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Tissue category (RNA)
Cell type category (RNA)
Cell line category (RNA)
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Enhanced
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Enhanced - Capture
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Enhanced - Independent
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Enhanced - Genetic
Enhanced - Independent
Enhanced - Recombinant
Supported
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Annotation
Intracellular and membrane
Secreted - unknown location
Secreted in brain
Secreted in female reproductive system
Secreted in male reproductive system
Secreted in other tissues
Secreted to blood
Secreted to digestive system
Secreted to extracellular matrix
Location
Actin filaments
Aggresome
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
Endoplasmic reticulum
Endosomes
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Peroxisomes
Plasma membrane
Rods & Rings
Vesicles
Searches
Enhanced
Supported
Approved
Uncertain
Intensity variation
Spatial variation
Cell cycle intensity correlation
Cell cycle spatial correlation
Cell cycle biologically
Custom data cell cycle dependant
Cell cycle dependent protein
Cell cycle independent protein
Cell cycle dependent transcript
Cell cycle independent transcript
Multilocalizing
Localizing 1
Localizing 2
Localizing 3
Localizing 4
Localizing 5
Localizing 6
Main location
Additional location
Location
Any
Actin filaments
Aggresome
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
Endoplasmic reticulum
Endosomes
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Peroxisomes
Plasma membrane
Rods & Rings
Vesicles
Cell line
Any
A-431
A549
AF22
ASC TERT1
BJ
CACO-2
EFO-21
FHDF/TERT166
GAMG
HaCaT
HAP1
HBEC3-KT
HBF TERT88
HDLM-2
HEK 293
HEL
HeLa
Hep G2
HTCEpi
HTEC/SVTERT24-B
HTERT-HME1
HTERT-RPE1
HUVEC TERT2
JURKAT
K-562
LHCN-M2
MCF7
NB-4
OE19
PC-3
REH
RH-30
RPTEC TERT1
RT4
SH-SY5Y
SiHa
SK-MEL-30
SuSa
THP-1
U-2 OS
U-251 MG
Type
Protein
Rna
Phase
G1
S
G2
M
Tissue
Any
Adipose tissue
Adrenal gland
Appendix
Bone marrow
Breast
Bronchus
Cartilage
Caudate
Cerebellum
Cerebral cortex
Cervix, uterine
Choroid plexus
Colon
Dorsal raphe
Duodenum
Endometrium
Epididymis
Esophagus
Eye
Fallopian tube
Gallbladder
Hair
Heart muscle
Hippocampus
Hypothalamus
Kidney
Lactating breast
Liver
Lung
Lymph node
Nasopharynx
Oral mucosa
Ovary
Pancreas
Parathyroid gland
Pituitary gland
Placenta
Prostate
Rectum
Retina
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Small intestine
Smooth muscle
Soft tissue
Sole of foot
Spleen
Stomach
Substantia nigra
Testis
Thymus
Thyroid gland
Tonsil
Urinary bladder
Vagina
Cell type
Expression
Not detected
Low
Medium
High
Tissue
Any
Adipose tissue
Adrenal gland
Blood
Bone marrow
Brain
Breast
Cervix, uterine
Ductus deferens
Endometrium
Epididymis
Esophagus
Fallopian tube
Gallbladder
Heart muscle
Intestine
Kidney
Liver
Lung
Lymphoid tissue
Ovary
Pancreas
Parathyroid gland
Pituitary gland
Placenta
Prostate
Retina
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Smooth muscle
Stomach
Testis
Thyroid gland
Tongue
Urinary bladder
Vagina
Category
Tissue enriched
Group enriched
Tissue enhanced
Low tissue specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cell type
Any
Alveolar cells type 1
Alveolar cells type 2
B-cells
Basal glandular cells
Basal keratinocytes
Bipolar cells
Cardiomyocytes
Cholangiocytes
Ciliated cells
Club cells
Collecting duct cells
Cone photoreceptor cells
Cytotrophoblasts
Distal tubular cells
Ductal cells
Early spermatids
Endothelial cells
Enterocytes
Erythroid cells
Exocrine glandular cells
Extravillous trophoblasts
Fibroblasts
Glandular cells
Granulocytes
Hepatocytes
Hofbauer cells
Horizontal cells
Intestinal endocrine cells
Ito cells
Kupffer cells
Late spermatids
Leydig cells
Macrophages
Melanocytes
Monocytes
Mucus-secreting cells
Muller glia cells
Pancreatic endocrine cells
Paneth cells
Peritubular cells
Proximal tubular cells
Rod photoreceptor cells
Sertoli cells
Smooth muscle cells
Spermatocytes
Spermatogonia
Suprabasal keratinocytes
Syncytiotrophoblasts
T-cells
Undifferentiated cells
Urothelial cells
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cell line
Any
A-431
A549
AF22
AN3-CA
ASC diff
ASC TERT1
BEWO
BJ
BJ hTERT+
BJ hTERT+ SV40 Large T+
BJ hTERT+ SV40 Large T+ RasG12V
CACO-2
CAPAN-2
Daudi
EFO-21
FHDF/TERT166
GAMG
HaCaT
HAP1
HBEC3-KT
HBF TERT88
HDLM-2
HEK 293
HEL
HeLa
Hep G2
HHSteC
HL-60
HMC-1
HSkMC
HTCEpi
HTEC/SVTERT24-B
HTERT-HME1
HTERT-RPE1
HUVEC TERT2
JURKAT
K-562
Karpas-707
LHCN-M2
MCF7
MOLT-4
NB-4
NTERA-2
OE19
PC-3
REH
RH-30
RPMI-8226
RPTEC TERT1
RT4
SCLC-21H
SH-SY5Y
SiHa
SK-BR-3
SK-MEL-30
SuSa
T-47d
THP-1
TIME
U-138 MG
U-2 OS
U-2197
U-251 MG
U-266/70
U-266/84
U-698
U-87 MG
U-937
WM-115
Category
Cell line enriched
Group enriched
Cell line enhanced
Low cell line specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cancer
Any
Breast cancer
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer
Category
Cancer enriched
Group enriched
Cancer enhanced
Low cancer specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Hippocampal formation
Hypothalamus
Midbrain
Olfactory region
Pons and medulla
Thalamus
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cell type
Any
Basophil
Classical monocyte
Eosinophil
GdT-cell
Intermediate monocyte
MAIT T-cell
Memory B-cell
Memory CD4 T-cell
Memory CD8 T-cell
Myeloid DC
Naive B-cell
Naive CD4 T-cell
Naive CD8 T-cell
Neutrophil
NK-cell
Non-classical monocyte
Plasmacytoid DC
T-reg
Total PBMC
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cell lineage
Any
B-cells
Dendritic cells
Granulocytes
Monocytes
NK-cells
T-cells
Category
Lineage enriched
Group enriched
Lineage enhanced
Low lineage specificity
Not detected
Detected in all
Detected in many
Detected in single
Is highest expressed
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Corpus callosum
Hippocampal formation
Hypothalamus
Midbrain
Olfactory region
Pituitary gland
Pons and medulla
Retina
Thalamus
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Corpus callosum
Hippocampal formation
Hypothalamus
Midbrain
Olfactory region
Pituitary gland
Pons and medulla
Retina
Spinal cord
Thalamus
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cancer
Breast cancer
Cervical cancer
Colorectal cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lung cancer
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Renal cancer
Renal cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer
Prognosis
Favorable
Unfavorable
Pathway
Acyl-CoA hydrolysis
Acylglycerides metabolism
Alanine; aspartate and glutamate metabolism
Amino sugar and nucleotide sugar metabolism
Aminoacyl-tRNA biosynthesis
Androgen metabolism
Arachidonic acid metabolism
Arginine and proline metabolism
Ascorbate and aldarate metabolism
Beta oxidation of branched-chain fatty acids (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)
Beta oxidation of even-chain fatty acids (mitochondrial)
Beta oxidation of even-chain fatty acids (peroxisomal)
Beta oxidation of odd-chain fatty acids (mitochondrial)
Beta oxidation of phytanic acid (peroxisomal)
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)
Beta-alanine metabolism
Bile acid biosynthesis
Bile acid recycling
Biopterin metabolism
Biotin metabolism
Blood group biosynthesis
Butanoate metabolism
C5-branched dibasic acid metabolism
Carnitine shuttle (cytosolic)
Carnitine shuttle (endoplasmic reticular)
Carnitine shuttle (mitochondrial)
Carnitine shuttle (peroxisomal)
Cholesterol biosynthesis 1 (Bloch pathway)
Cholesterol biosynthesis 2
Cholesterol biosynthesis 3 (Kandustch-Russell pathway)
Cholesterol metabolism
Chondroitin / heparan sulfate biosynthesis
Chondroitin sulfate degradation
CoA synthesis
Cysteine and methionine metabolism
Drug metabolism
Eicosanoid metabolism
Estrogen metabolism
Ether lipid metabolism
Exchange/demand reactions
Fatty acid activation (cytosolic)
Fatty acid activation (endoplasmic reticular)
Fatty acid biosynthesis
Fatty acid biosynthesis (even-chain)
Fatty acid biosynthesis (odd-chain)
Fatty acid biosynthesis (unsaturated)
Fatty acid desaturation (even-chain)
Fatty acid desaturation (odd-chain)
Fatty acid elongation (even-chain)
Fatty acid elongation (odd-chain)
Fatty acid oxidation
Folate metabolism
Formation and hydrolysis of cholesterol esters
Fructose and mannose metabolism
Galactose metabolism
Glucocorticoid biosynthesis
Glutathione metabolism
Glycerolipid metabolism
Glycerophospholipid metabolism
Glycine; serine and threonine metabolism
Glycolysis / Gluconeogenesis
Glycosphingolipid biosynthesis-ganglio series
Glycosphingolipid biosynthesis-globo series
Glycosphingolipid biosynthesis-lacto and neolacto series
Glycosphingolipid metabolism
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Heme degradation
Heme synthesis
Heparan sulfate degradation
Histidine metabolism
Inositol phosphate metabolism
Isolated
Keratan sulfate biosynthesis
Keratan sulfate degradation
Leukotriene metabolism
Linoleate metabolism
Lipoic acid metabolism
Lysine metabolism
Metabolism of other amino acids
Metabolism of xenobiotics by cytochrome P450
Miscellaneous
N-glycan metabolism
Nicotinate and nicotinamide metabolism
Nitrogen metabolism
Nucleotide metabolism
O-glycan metabolism
Omega-3 fatty acid metabolism
Omega-6 fatty acid metabolism
Oxidative phosphorylation
Pantothenate and CoA biosynthesis
Pentose and glucuronate interconversions
Pentose phosphate pathway
Phenylalanine metabolism
Phenylalanine; tyrosine and tryptophan biosynthesis
Phosphatidylinositol phosphate metabolism
Pool reactions
Porphyrin metabolism
Propanoate metabolism
Prostaglandin biosynthesis
Protein assembly
Protein degradation
Protein modification
Purine metabolism
Pyrimidine metabolism
Pyruvate metabolism
Retinol metabolism
Riboflavin metabolism
ROS detoxification
Serotonin and melatonin biosynthesis
Sphingolipid metabolism
Starch and sucrose metabolism
Steroid metabolism
Sulfur metabolism
Terpenoid backbone biosynthesis
Thiamine metabolism
Transport reactions
Triacylglycerol synthesis
Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism
Tryptophan metabolism
Tyrosine metabolism
Ubiquinone synthesis
Urea cycle
Valine; leucine; and isoleucine metabolism
Vitamin A metabolism
Vitamin B12 metabolism
Vitamin B2 metabolism
Vitamin B6 metabolism
Vitamin C metabolism
Vitamin D metabolism
Vitamin E metabolism
Xenobiotics metabolism
Category
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Antibodies
Yes
No
In atlas
Tissue
Cell
Pathology
Brain
Blood - conc. immunoassay
Blood - conc. mass spectrometry
Blood - detected pea
Column
Gene
Position
Tissue specific score
Prognostic
Reliability (IF)
Reliability (IH)
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TMEM35A
SUMMARY
TISSUE
CELL TYPE
PATHOLOGY
BRAIN
BLOOD
CELL
BRAIN ATLAS
TISSUES
ACG, PREGENUAL-DORSAL
ACG, PREGENUAL-VENTRAL
ACG, SUBGENUAL
AMYGDALA
BASAL GANGLIA
CEREBELLUM
CEREBRAL CORTEX
CORPUS CALLOSUM
DORSOLATERAL PFC
DORSOMEDIAL PFC
FRONTAL CORTEX
FRONTOMARGINAL CORTEX
FRONTOPOLAR CORTEX
GYRUS RECTUS
HIPPOCAMPAL FORMATION
HYPOTHALAMUS
IFG, ORBITAL
IFG, TRIANGULAR
MIDBRAIN
OLFACTORY REGION
ORG, LATERAL
ORG, MEDIAL
ORG, POSTERIOR
PARIETAL CORTEX
PITUTIARY
PONS AND MEDULLA
RETINA
SPINAL CORD
SUBCALLOSAL GYRUS
SUPERIOR FRONTAL GYRUS
TEMPORAL CORTEX
THALAMUS
VENTROLATERAL PFC
VENTROMEDIAL PFC
PRIMARY MOUSE DATA
GENE/PROTEIN
ANTIBODIES
AND
VALIDATION
Brain proteome
MOUSE BRAIN TISSUE
Gene description
Transmembrane protein 35A
Mouse gene
ENSMUSG00000033578
(version 92)
Annotation summary
This transmembrane protein is highly (although not exclusively) expressed in neurons in the arcuate and ventral medial hypothalamic nuclei.
Positive cells and structures
i
Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.
Read more
Soma, dendrite and synapse in neurons.
FRONT
BACK
Human hippocampus
Olfactory bulb
Hypothalamus
Amygdala
Hypothalamus
Protein
Relative fluorescence intensity
i
Protein expression in
mouse brain
using immunofluorescence is reported as
mean fluorescence intensity
.
Read more
Mouse brain region
255
0
Cerebral cortex
Frontal association cortex (fra)
Motor cortex (m)
Cingulate cortex (cg)
Piriform cortex, L1 (pirl1)
Piriform cortex, L2 (pirl2)
Piriform cortex, L3 (pirl3)
Insular cortex (i)
Somatosensory cortex (s)
Retrosplenial granular cortex (rsg)
Parietal association cortex (p)
Entorhinal cortex (ent)
Visual cortex (v)
Olfactory bulb
Anterior olfactory nucleus (aon)
Granule cell layer (gro)
Internal plexiform layer (ipl)
Mitral cell layer (mi)
Glomerular layer (gl)
Rostral migratory stream (rms)
External plexiform layer (epl)
External plexiform layer of the accessory OB (epla)
Granule cell layer of the accessory OB (gra)
Glomerular layer of the accessory OB (gla)
Hippocampus
Polymorph layer of the dentate gyrus (podg)
Molecular layer of the dentate gyrus (modg)
Granular dentate gyrus (grdg)
CA1 - oriens layer (ca1or)
CA1 - pyramidal layer (ca1py)
CA1 - radiatum layer (ca1ra)
CA2 - oriens layer (ca2or)
CA2 - pyramidal layer (ca2py)
CA2 - radiatum layer (ca2ra)
CA3 - oriens layer (ca3or)
CA3 - pyramidal layer (ca3py)
CA3 - radiatum layer (ca3ra)
Stratum lucidum (slu)
Lacunosum moleculare (lmol)
Subiculum (sub)
Amygdala
Nucleus of the lateral olfactory tract (lot)
N/A
Basal medial amygdaloid nucleus (bma)
Basal lateral amygdala* (*bla)
Basal lateral amygdaloid nucleus (bla)
N/A
Cortical amygdala (aco)
Central amygdala (ce)
Medial amygdaloid nucleus (mea)
Thalamus
Medial geniculate nucleus (mg)
Parafascicular thalamic nucleus (pf)
Pregeniculate nucleus (pg)
Stria terminalis (st)
Zona incerta (zi)
Anterodorsal thalamic nucleus (ad)
Reticular thalamic nucleus (rt)
Vental anterior thalamic nucleus (va)
N/A
Medial habenular nucleus (mhb)
Laterodorsal thalamic area (ld)
Paraventricular thalamic nucleus (pv)
Central medial thalamic area (cm)
Ventral lateral thalamic area (vl)
N/A
Ventral medial thalamic area (vm)
Lateral habenulal nucleus (lhb)
Ventral posterior thalamus (vpt)
Anterior pretactal nucleus (apt)
Retromammillary nucleus (rm)
N/A
Hypothalamus
Dorsal tuberomammillary nucleus (dtm)
Mammillary nucleus (mn)
Periventricular hypothalamic nucleus (pe)
Supraoptic nucleus (so)
Tuberal nucleus (tu)
Ventral tuberomammillary nucleus (vtm)
N/A
Lateral preoptic area (lpo)
N/A
Medial preoptic area (mpo)
N/A
Suprachiasmatic nucleus (sch)
N/A
Paraventricular hypothalamic nucleus (pa)
Anterior hypothalamic area, central (ahc)
N/A
Ventral medial hypothalamic nucleus (vmh)
Ventral medial hypothalamic nucleus* (*vmh)
Arcuate nucleus (arc)
Arcuate nucleus* (*arc)
Peduncular part of lateral hypothalmus (plh)
Dorsal medial hypothalamic nucleus (dm)
Stria terminalis* (*st)
Pons
Barrington's nucleus (bar)
N/A
Koelliker-fuse nucleus (kf)
N/A
Motor tregiminal nucleus (5n)
Parabrachial nucleus (pbp)
Principle sensory trigeminal nucleus (pr5)
Locus coeruleus (lc)
Pontine nucleus (pn)
N/A
Vestibular nucleus (ve)
Pontine reticular nucleus, oral (pno)
Lateral lemniscus (ll)
Superior paraolivary nucleus (spo)
Medulla
Nucleus of the solitary tract (sol)
Raphe magnus nucleus (rmg)
Cochlear nucleus (cn)
Lateral paragigantocellular nucleus (lpg)
Raphe pallidus nucleus (rpa)
Facial nucleus (7n)
Hypoglossal nucleus (12n)
Ambiguus nucleus (amb)
External cuneate nucleus (ecu)
Inferior olivary nucleus (io)
Raphe obscures nucleus (rob)
Dorsal motor nucleus of vagus (10n)
Cerebellum
Vestibulocerebellar nucleus (vecb)
N/A
Moleuclar layer of the cerebellum (cemol)
Purkinje layer of the cerebellum (cepur)
Granular layer of the cerebellum (cegr)
Circumventricular organs
Subcommissural organ (sco)
Subfornical organ (sfo)
N/A
Median eminence (me)
Medulla (ap)
Antibodies in assay
i
The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.
HPA048583