Cell type atlas - EMG1 - The Human Protein Atlas

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EMG1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EMG1
Gene descriptionⁱ Full gene name according to HGNC.	EMG1, N1-specific pseudouridine methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	36 NX
Colon	61 NX
Kidney	36 NX
Liver	18 NX

Basal glandular cells	64 NX
Prostate	64 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	97 NX
Placenta	97 NX

Distal tubular cells	41 NX
Kidney	41 NX

Ductal cells	65 NX
Pancreas	64 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	32 NX
Pancreas	68 NX
Prostate	49 NX
Placenta	47 NX
Skin	35 NX
Liver	32 NX
Testis	30 NX
Lung	23 NX
Eye	15 NX
Heart muscle	0 NX

Enterocytes	19 NX
Small intestine	22 NX
Colon	17 NX
Rectum	16 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	99 NX
Placenta	99 NX

Fibroblasts	32 NX
Prostate	55 NX
Placenta	44 NX
Lung	32 NX
Skin	26 NX
Heart muscle	0 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	60 NX
Colon	74 NX
Lung	47 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	57 NX
Placenta	57 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	9 NX
Rectum	12 NX
Colon	7 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	41 NX
Pancreas	66 NX
Kidney	54 NX
Lung	45 NX
Testis	35 NX
Skin	31 NX
Prostate	23 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	54 NX
Pancreas	54 NX

Mucus-secreting cells	22 NX
Rectum	28 NX
Colon	21 NX
Small intestine	19 NX

Muller glia cells	16 NX
Eye	16 NX

Pancreatic endocrine cells	61 NX
Pancreas	60 NX

Paneth cells	18 NX
Rectum	31 NX
Small intestine	18 NX
Colon	6 NX

Peritubular cells	24 NX
Testis	24 NX

Proximal tubular cells	66 NX
Kidney	66 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	20 NX
Pancreas	89 NX
Prostate	41 NX
Skin	19 NX
Heart muscle	0 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	54 NX
Testis	54 NX

Suprabasal keratinocytes	35 NX
Skin	35 NX

Syncytiotrophoblasts	62 NX
Placenta	62 NX

T-cells	33 NX
Kidney	44 NX
Lung	40 NX
Colon	33 NX
Liver	31 NX
Skin	29 NX
Prostate	22 NX

Undifferentiated cells	32 NX
Small intestine	32 NX
Colon	32 NX
Rectum	30 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.