Cell type atlas - SBDS - The Human Protein Atlas

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SBDS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SBDS
Gene descriptionⁱ Full gene name according to HGNC.	SBDS, ribosome maturation factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	283 NX
Lung	283 NX

Alveolar cells type 2	101 NX
Lung	101 NX

B-cells	67 NX
Colon	87 NX
Kidney	80 NX
Liver	33 NX

Basal glandular cells	339 NX
Prostate	339 NX

Basal keratinocytes	412 NX
Skin	412 NX

Bipolar cells	74 NX
Eye	74 NX

Cardiomyocytes	274 NX
Heart muscle	274 NX

Cholangiocytes	79 NX
Liver	79 NX

Ciliated cells	59 NX
Lung	59 NX

Club cells	129 NX
Lung	129 NX

Collecting duct cells	87 NX
Kidney	87 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	116 NX
Placenta	116 NX

Distal tubular cells	222 NX
Kidney	222 NX

Ductal cells	162 NX
Pancreas	162 NX

Early spermatids	545 NX
Testis	545 NX

Endothelial cells	140 NX
Skin	286 NX
Prostate	214 NX
Lung	172 NX
Heart muscle	144 NX
Pancreas	140 NX
Placenta	136 NX
Liver	126 NX
Testis	101 NX
Eye	82 NX

Enterocytes	268 NX
Small intestine	319 NX
Rectum	232 NX
Colon	228 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	145 NX
Pancreas	145 NX

Extravillous trophoblasts	193 NX
Placenta	193 NX

Fibroblasts	211 NX
Prostate	369 NX
Skin	332 NX
Heart muscle	206 NX
Lung	200 NX
Placenta	173 NX

Glandular cells	213 NX
Prostate	213 NX

Granulocytes	145 NX
Lung	170 NX
Colon	119 NX

Hepatocytes	97 NX
Liver	97 NX

Hofbauer cells	95 NX
Placenta	95 NX

Horizontal cells	56 NX
Eye	56 NX

Intestinal endocrine cells	98 NX
Rectum	101 NX
Colon	95 NX

Ito cells	128 NX
Liver	128 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	1381 NX
Testis	1381 NX

Leydig cells	118 NX
Testis	118 NX

Macrophages	84 NX
Skin	190 NX
Prostate	109 NX
Lung	84 NX
Pancreas	70 NX
Testis	53 NX
Kidney	48 NX

Melanocytes	243 NX
Skin	243 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	99 NX
Pancreas	99 NX

Mucus-secreting cells	183 NX
Small intestine	237 NX
Colon	225 NX
Rectum	167 NX

Muller glia cells	124 NX
Eye	124 NX

Pancreatic endocrine cells	213 NX
Pancreas	213 NX

Paneth cells	200 NX
Colon	323 NX
Small intestine	200 NX
Rectum	130 NX

Peritubular cells	158 NX
Testis	158 NX

Proximal tubular cells	223 NX
Kidney	223 NX

Rod photoreceptor cells	47 NX
Eye	47 NX

Sertoli cells	162 NX
Testis	162 NX

Smooth muscle cells	334 NX
Prostate	466 NX
Skin	396 NX
Heart muscle	268 NX
Pancreas	257 NX

Spermatocytes	75 NX
Testis	75 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	376 NX
Skin	376 NX

Syncytiotrophoblasts	333 NX
Placenta	333 NX

T-cells	96 NX
Prostate	288 NX
Skin	235 NX
Lung	129 NX
Colon	101 NX
Kidney	96 NX
Liver	55 NX

Undifferentiated cells	134 NX
Colon	151 NX
Small intestine	149 NX
Rectum	106 NX

Urothelial cells	300 NX
Prostate	300 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.