Cell type atlas - ID1 - The Human Protein Atlas

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ID1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ID1
Gene descriptionⁱ Full gene name according to HGNC.	Inhibitor of DNA binding 1, HLH protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (EFO-21, HaCaT, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	220 NX
Lung	220 NX

Alveolar cells type 2	144 NX
Lung	144 NX

B-cells	27 NX
Kidney	71 NX
Liver	23 NX
Colon	21 NX

Basal glandular cells	632 NX
Prostate	632 NX

Basal keratinocytes	91 NX
Skin	91 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	77 NX
Liver	77 NX

Ciliated cells	90 NX
Lung	90 NX

Club cells	272 NX
Lung	272 NX

Collecting duct cells	216 NX
Kidney	216 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	104 NX
Placenta	104 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	429 NX
Pancreas	429 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	484 NX
Liver	2259 NX
Testis	1700 NX
Eye	897 NX
Pancreas	559 NX
Placenta	515 NX
Heart muscle	420 NX
Skin	247 NX
Prostate	162 NX
Lung	137 NX

Enterocytes	528 NX
Colon	578 NX
Rectum	545 NX
Small intestine	487 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	472 NX
Pancreas	472 NX

Extravillous trophoblasts	442 NX
Placenta	442 NX

Fibroblasts	137 NX
Prostate	431 NX
Lung	331 NX
Skin	148 NX
Placenta	112 NX
Heart muscle	61 NX

Glandular cells	501 NX
Prostate	501 NX

Granulocytes	22 NX
Colon	28 NX
Lung	16 NX

Hepatocytes	91 NX
Liver	91 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	551 NX
Rectum	721 NX
Colon	381 NX

Ito cells	1636 NX
Liver	1636 NX

Kupffer cells	77 NX
Liver	77 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	26 NX
Prostate	53 NX
Skin	43 NX
Lung	23 NX
Kidney	13 NX
Pancreas	12 NX
Testis	5 NX

Melanocytes	86 NX
Skin	86 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	14 NX
Pancreas	14 NX

Mucus-secreting cells	451 NX
Colon	652 NX
Small intestine	557 NX
Rectum	249 NX

Muller glia cells	81 NX
Eye	81 NX

Pancreatic endocrine cells	190 NX
Pancreas	190 NX

Paneth cells	770 NX
Small intestine	1007 NX
Rectum	770 NX
Colon	740 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	193 NX
Pancreas	257 NX
Prostate	215 NX
Skin	144 NX
Heart muscle	97 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	77 NX
Skin	77 NX

Syncytiotrophoblasts	75 NX
Placenta	75 NX

T-cells	25 NX
Prostate	48 NX
Skin	34 NX
Colon	29 NX
Lung	20 NX
Liver	19 NX
Kidney	11 NX

Undifferentiated cells	242 NX
Colon	362 NX
Small intestine	280 NX
Rectum	177 NX

Urothelial cells	478 NX
Prostate	478 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.