Cell type atlas - NDUFA1 - The Human Protein Atlas

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NDUFA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA1
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	149 NX
Lung	149 NX

Alveolar cells type 2	173 NX
Lung	173 NX

B-cells	221 NX
Liver	402 NX
Kidney	276 NX
Colon	166 NX

Basal glandular cells	196 NX
Prostate	196 NX

Basal keratinocytes	190 NX
Skin	190 NX

Bipolar cells	139 NX
Eye	139 NX

Cardiomyocytes	3053 NX
Heart muscle	3053 NX

Cholangiocytes	637 NX
Liver	637 NX

Ciliated cells	331 NX
Lung	331 NX

Club cells	206 NX
Lung	206 NX

Collecting duct cells	534 NX
Kidney	534 NX

Cone photoreceptor cells	75 NX
Eye	75 NX

Cytotrophoblasts	332 NX
Placenta	332 NX

Distal tubular cells	1857 NX
Kidney	1857 NX

Ductal cells	408 NX
Pancreas	408 NX

Early spermatids	28 NX
Testis	28 NX

Endothelial cells	250 NX
Heart muscle	422 NX
Pancreas	304 NX
Placenta	284 NX
Liver	250 NX
Skin	237 NX
Testis	225 NX
Lung	190 NX
Eye	160 NX
Prostate	128 NX

Enterocytes	1245 NX
Small intestine	1279 NX
Rectum	1178 NX
Colon	1069 NX

Erythroid cells	257 NX
Liver	257 NX

Exocrine glandular cells	445 NX
Pancreas	445 NX

Extravillous trophoblasts	352 NX
Placenta	352 NX

Fibroblasts	251 NX
Heart muscle	727 NX
Placenta	311 NX
Skin	233 NX
Lung	224 NX
Prostate	117 NX

Glandular cells	215 NX
Prostate	215 NX

Granulocytes	205 NX
Lung	207 NX
Colon	202 NX

Hepatocytes	881 NX
Liver	881 NX

Hofbauer cells	567 NX
Placenta	567 NX

Horizontal cells	78 NX
Eye	78 NX

Intestinal endocrine cells	441 NX
Rectum	529 NX
Colon	353 NX

Ito cells	255 NX
Liver	255 NX

Kupffer cells	409 NX
Liver	409 NX

Late spermatids	27 NX
Testis	27 NX

Leydig cells	273 NX
Testis	273 NX

Macrophages	347 NX
Pancreas	669 NX
Kidney	618 NX
Lung	360 NX
Skin	339 NX
Testis	278 NX
Prostate	209 NX

Melanocytes	542 NX
Skin	542 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	587 NX
Pancreas	587 NX

Mucus-secreting cells	745 NX
Colon	951 NX
Rectum	753 NX
Small intestine	635 NX

Muller glia cells	168 NX
Eye	168 NX

Pancreatic endocrine cells	446 NX
Pancreas	446 NX

Paneth cells	707 NX
Colon	1393 NX
Rectum	707 NX
Small intestine	652 NX

Peritubular cells	268 NX
Testis	268 NX

Proximal tubular cells	1090 NX
Kidney	1090 NX

Rod photoreceptor cells	161 NX
Eye	161 NX

Sertoli cells	213 NX
Testis	213 NX

Smooth muscle cells	270 NX
Heart muscle	612 NX
Pancreas	316 NX
Skin	251 NX
Prostate	144 NX

Spermatocytes	46 NX
Testis	46 NX

Spermatogonia	79 NX
Testis	79 NX

Suprabasal keratinocytes	218 NX
Skin	218 NX

Syncytiotrophoblasts	318 NX
Placenta	318 NX

T-cells	244 NX
Kidney	372 NX
Skin	333 NX
Lung	255 NX
Colon	218 NX
Liver	215 NX
Prostate	196 NX

Undifferentiated cells	663 NX
Rectum	957 NX
Small intestine	642 NX
Colon	598 NX

Urothelial cells	283 NX
Prostate	283 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.