Cell type atlas - GLO1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GLO1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLO1
Gene descriptionⁱ Full gene name according to HGNC.	Glyoxalase I
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (HMC-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	122 NX
Lung	122 NX

Alveolar cells type 2	137 NX
Lung	137 NX

B-cells	87 NX
Liver	103 NX
Kidney	76 NX
Colon	42 NX

Basal glandular cells	80 NX
Prostate	80 NX

Basal keratinocytes	58 NX
Skin	58 NX

Bipolar cells	55 NX
Eye	55 NX

Cardiomyocytes	121 NX
Heart muscle	121 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	88 NX
Lung	88 NX

Club cells	91 NX
Lung	91 NX

Collecting duct cells	86 NX
Kidney	86 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	91 NX
Placenta	91 NX

Distal tubular cells	211 NX
Kidney	211 NX

Ductal cells	107 NX
Pancreas	107 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	71 NX
Placenta	122 NX
Testis	97 NX
Prostate	96 NX
Pancreas	82 NX
Eye	82 NX
Lung	64 NX
Skin	57 NX
Heart muscle	53 NX
Liver	49 NX

Enterocytes	36 NX
Small intestine	78 NX
Rectum	32 NX
Colon	23 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	64 NX
Pancreas	64 NX

Extravillous trophoblasts	264 NX
Placenta	264 NX

Fibroblasts	69 NX
Placenta	144 NX
Skin	66 NX
Prostate	64 NX
Lung	62 NX
Heart muscle	60 NX

Glandular cells	193 NX
Prostate	193 NX

Granulocytes	67 NX
Lung	107 NX
Colon	28 NX

Hepatocytes	87 NX
Liver	87 NX

Hofbauer cells	68 NX
Placenta	68 NX

Horizontal cells	65 NX
Eye	65 NX

Intestinal endocrine cells	35 NX
Colon	37 NX
Rectum	33 NX

Ito cells	200 NX
Liver	200 NX

Kupffer cells	112 NX
Liver	112 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	78 NX
Testis	78 NX

Macrophages	69 NX
Pancreas	122 NX
Prostate	110 NX
Lung	89 NX
Skin	69 NX
Testis	57 NX
Kidney	39 NX

Melanocytes	100 NX
Skin	100 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	130 NX
Pancreas	130 NX

Mucus-secreting cells	41 NX
Rectum	45 NX
Small intestine	35 NX
Colon	25 NX

Muller glia cells	161 NX
Eye	161 NX

Pancreatic endocrine cells	66 NX
Pancreas	66 NX

Paneth cells	36 NX
Small intestine	46 NX
Rectum	36 NX
Colon	17 NX

Peritubular cells	103 NX
Testis	103 NX

Proximal tubular cells	107 NX
Kidney	107 NX

Rod photoreceptor cells	51 NX
Eye	51 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	66 NX
Pancreas	127 NX
Prostate	76 NX
Heart muscle	66 NX
Skin	61 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	77 NX
Skin	77 NX

Syncytiotrophoblasts	61 NX
Placenta	61 NX

T-cells	60 NX
Skin	95 NX
Lung	76 NX
Colon	76 NX
Kidney	60 NX
Prostate	52 NX
Liver	52 NX

Undifferentiated cells	56 NX
Small intestine	73 NX
Rectum	48 NX
Colon	46 NX

Urothelial cells	125 NX
Prostate	125 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.