Cell type atlas - NAGK - The Human Protein Atlas

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NAGK

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NAGK
Gene descriptionⁱ Full gene name according to HGNC.	N-acetylglucosamine kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	39 NX
Lung	39 NX

B-cells	52 NX
Kidney	62 NX
Colon	58 NX
Liver	30 NX

Basal glandular cells	25 NX
Prostate	25 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	43 NX
Eye	43 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	111 NX
Placenta	111 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	61 NX
Pancreas	61 NX

Early spermatids	115 NX
Testis	115 NX

Endothelial cells	28 NX
Placenta	57 NX
Eye	46 NX
Pancreas	36 NX
Testis	31 NX
Liver	29 NX
Skin	26 NX
Heart muscle	24 NX
Lung	23 NX
Prostate	16 NX

Enterocytes	14 NX
Small intestine	20 NX
Rectum	12 NX
Colon	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	40 NX
Pancreas	40 NX

Extravillous trophoblasts	107 NX
Placenta	107 NX

Fibroblasts	37 NX
Placenta	68 NX
Skin	36 NX
Lung	27 NX
Heart muscle	22 NX
Prostate	20 NX

Glandular cells	15 NX
Prostate	15 NX

Granulocytes	50 NX
Lung	63 NX
Colon	37 NX

Hepatocytes	12 NX
Liver	12 NX

Hofbauer cells	191 NX
Placenta	191 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	22 NX
Colon	24 NX
Rectum	21 NX

Ito cells	31 NX
Liver	31 NX

Kupffer cells	107 NX
Liver	107 NX

Late spermatids	17 NX
Testis	17 NX

Leydig cells	28 NX
Testis	28 NX

Macrophages	98 NX
Kidney	161 NX
Pancreas	126 NX
Lung	108 NX
Testis	92 NX
Skin	79 NX
Prostate	72 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	45 NX
Pancreas	45 NX

Mucus-secreting cells	18 NX
Colon	21 NX
Small intestine	19 NX
Rectum	14 NX

Muller glia cells	43 NX
Eye	43 NX

Pancreatic endocrine cells	53 NX
Pancreas	53 NX

Paneth cells	23 NX
Small intestine	46 NX
Rectum	23 NX
Colon	20 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	47 NX
Kidney	47 NX

Rod photoreceptor cells	54 NX
Eye	54 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	33 NX
Pancreas	98 NX
Skin	34 NX
Prostate	25 NX
Heart muscle	21 NX

Spermatocytes	34 NX
Testis	34 NX

Spermatogonia	23 NX
Testis	23 NX

Suprabasal keratinocytes	36 NX
Skin	36 NX

Syncytiotrophoblasts	267 NX
Placenta	267 NX

T-cells	24 NX
Lung	73 NX
Colon	30 NX
Kidney	29 NX
Skin	24 NX
Prostate	22 NX
Liver	18 NX

Undifferentiated cells	14 NX
Small intestine	16 NX
Rectum	14 NX
Colon	14 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.