Cell type atlas - STAMBP - The Human Protein Atlas

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STAMBP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAMBP
Gene descriptionⁱ Full gene name according to HGNC.	STAM binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (LHCN-M2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	14 NX
Kidney	18 NX
Liver	15 NX
Colon	11 NX

Basal glandular cells	25 NX
Prostate	25 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	20 NX
Eye	20 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	35 NX
Placenta	35 NX

Distal tubular cells	41 NX
Kidney	41 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	59 NX
Testis	59 NX

Endothelial cells	22 NX
Testis	30 NX
Heart muscle	29 NX
Liver	25 NX
Eye	23 NX
Placenta	22 NX
Prostate	17 NX
Skin	15 NX
Pancreas	11 NX
Lung	9 NX

Enterocytes	41 NX
Small intestine	48 NX
Rectum	44 NX
Colon	36 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	23 NX
Heart muscle	31 NX
Placenta	27 NX
Lung	23 NX
Skin	14 NX
Prostate	13 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	52 NX
Colon	64 NX
Lung	40 NX

Hepatocytes	35 NX
Liver	35 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	10 NX
Rectum	16 NX
Colon	3 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	105 NX
Testis	105 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	29 NX
Lung	35 NX
Prostate	32 NX
Kidney	31 NX
Testis	28 NX
Skin	17 NX
Pancreas	16 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	37 NX
Pancreas	37 NX

Mucus-secreting cells	32 NX
Small intestine	35 NX
Colon	33 NX
Rectum	31 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	39 NX
Rectum	40 NX
Small intestine	39 NX
Colon	35 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	47 NX
Kidney	47 NX

Rod photoreceptor cells	19 NX
Eye	19 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	21 NX
Heart muscle	38 NX
Prostate	25 NX
Skin	19 NX
Pancreas	16 NX

Spermatocytes	32 NX
Testis	32 NX

Spermatogonia	50 NX
Testis	50 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	37 NX
Placenta	37 NX

T-cells	20 NX
Lung	33 NX
Kidney	26 NX
Skin	20 NX
Liver	18 NX
Colon	14 NX
Prostate	9 NX

Undifferentiated cells	31 NX
Small intestine	34 NX
Rectum	31 NX
Colon	20 NX

Urothelial cells	23 NX
Prostate	23 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.