Cell type atlas - PEPD - The Human Protein Atlas

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PEPD

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PEPD
Gene descriptionⁱ Full gene name according to HGNC.	Peptidase D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	24 NX
Lung	24 NX

B-cells	20 NX
Kidney	62 NX
Liver	15 NX
Colon	11 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	70 NX
Kidney	70 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	19 NX
Placenta	19 NX

Distal tubular cells	168 NX
Kidney	168 NX

Ductal cells	63 NX
Pancreas	63 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	45 NX
Pancreas	93 NX
Lung	58 NX
Eye	56 NX
Skin	56 NX
Testis	50 NX
Placenta	45 NX
Liver	38 NX
Prostate	32 NX
Heart muscle	26 NX

Enterocytes	38 NX
Small intestine	667 NX
Colon	19 NX
Rectum	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	38 NX
Pancreas	38 NX

Extravillous trophoblasts	60 NX
Placenta	60 NX

Fibroblasts	35 NX
Skin	42 NX
Prostate	34 NX
Placenta	30 NX
Heart muscle	28 NX
Lung	19 NX

Glandular cells	21 NX
Prostate	21 NX

Granulocytes	56 NX
Lung	65 NX
Colon	46 NX

Hepatocytes	162 NX
Liver	162 NX

Hofbauer cells	190 NX
Placenta	190 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	17 NX
Colon	24 NX
Rectum	9 NX

Ito cells	35 NX
Liver	35 NX

Kupffer cells	47 NX
Liver	47 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	63 NX
Pancreas	201 NX
Kidney	126 NX
Prostate	64 NX
Testis	54 NX
Skin	48 NX
Lung	47 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	132 NX
Pancreas	132 NX

Mucus-secreting cells	15 NX
Small intestine	81 NX
Rectum	13 NX
Colon	7 NX

Muller glia cells	69 NX
Eye	69 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	29 NX
Small intestine	168 NX
Rectum	29 NX
Colon	23 NX

Peritubular cells	57 NX
Testis	57 NX

Proximal tubular cells	1021 NX
Kidney	1021 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	39 NX
Pancreas	78 NX
Heart muscle	39 NX
Skin	36 NX
Prostate	36 NX

Spermatocytes	11 NX
Testis	11 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	25 NX
Placenta	25 NX

T-cells	31 NX
Kidney	97 NX
Liver	42 NX
Colon	31 NX
Lung	29 NX
Skin	22 NX
Prostate	4 NX

Undifferentiated cells	17 NX
Small intestine	84 NX
Rectum	15 NX
Colon	12 NX

Urothelial cells	18 NX
Prostate	18 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.