Cell type atlas - ZNFX1 - The Human Protein Atlas

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ZNFX1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNFX1
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger NFX1-type containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+ SV40 Large T+)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	17 NX
Colon	34 NX
Liver	17 NX
Kidney	5 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	11 NX
Heart muscle	11 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	29 NX
Lung	29 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	6 NX
Placenta	5 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	28 NX
Testis	28 NX

Endothelial cells	39 NX
Lung	76 NX
Eye	44 NX
Prostate	42 NX
Liver	41 NX
Heart muscle	41 NX
Skin	32 NX
Testis	25 NX
Placenta	14 NX
Pancreas	4 NX

Enterocytes	16 NX
Rectum	23 NX
Colon	16 NX
Small intestine	15 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	20 NX
Pancreas	20 NX

Extravillous trophoblasts	6 NX
Placenta	6 NX

Fibroblasts	27 NX
Lung	46 NX
Prostate	39 NX
Skin	28 NX
Heart muscle	22 NX
Placenta	10 NX

Glandular cells	22 NX
Prostate	22 NX

Granulocytes	27 NX
Colon	28 NX
Lung	26 NX

Hepatocytes	12 NX
Liver	12 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	11 NX
Eye	11 NX

Intestinal endocrine cells	13 NX
Colon	14 NX
Rectum	12 NX

Ito cells	26 NX
Liver	26 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	16 NX
Testis	16 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	26 NX
Lung	56 NX
Skin	30 NX
Prostate	26 NX
Pancreas	23 NX
Kidney	17 NX
Testis	16 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	11 NX
Small intestine	20 NX
Rectum	11 NX
Colon	9 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	25 NX
Pancreas	25 NX

Paneth cells	18 NX
Colon	29 NX
Small intestine	18 NX
Rectum	12 NX

Peritubular cells	26 NX
Testis	26 NX

Proximal tubular cells	6 NX
Kidney	6 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	28 NX
Heart muscle	54 NX
Skin	32 NX
Prostate	28 NX
Pancreas	15 NX

Spermatocytes	42 NX
Testis	42 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	10 NX
Placenta	10 NX

T-cells	15 NX
Colon	32 NX
Lung	27 NX
Skin	21 NX
Kidney	17 NX
Prostate	13 NX
Liver	13 NX

Undifferentiated cells	10 NX
Rectum	11 NX
Small intestine	8 NX
Colon	6 NX

Urothelial cells	31 NX
Prostate	31 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.