Cell type atlas - PIGT - The Human Protein Atlas

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PIGT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIGT
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol glycan anchor biosynthesis class T
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	37 NX
Colon	46 NX
Liver	37 NX
Kidney	18 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	17 NX
Eye	17 NX

Cardiomyocytes	144 NX
Heart muscle	144 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	54 NX
Placenta	54 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	96 NX
Pancreas	96 NX

Early spermatids	26 NX
Testis	26 NX

Endothelial cells	50 NX
Heart muscle	69 NX
Pancreas	68 NX
Placenta	67 NX
Skin	52 NX
Eye	50 NX
Lung	29 NX
Prostate	28 NX
Testis	27 NX
Liver	22 NX

Enterocytes	92 NX
Colon	113 NX
Rectum	91 NX
Small intestine	90 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	101 NX
Pancreas	101 NX

Extravillous trophoblasts	63 NX
Placenta	63 NX

Fibroblasts	73 NX
Skin	90 NX
Heart muscle	70 NX
Placenta	68 NX
Prostate	42 NX
Lung	31 NX

Glandular cells	39 NX
Prostate	39 NX

Granulocytes	32 NX
Lung	37 NX
Colon	28 NX

Hepatocytes	35 NX
Liver	35 NX

Hofbauer cells	69 NX
Placenta	69 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	63 NX
Rectum	75 NX
Colon	51 NX

Ito cells	45 NX
Liver	45 NX

Kupffer cells	49 NX
Liver	49 NX

Late spermatids	59 NX
Testis	59 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	37 NX
Pancreas	89 NX
Kidney	47 NX
Prostate	36 NX
Skin	36 NX
Lung	35 NX
Testis	35 NX

Melanocytes	84 NX
Skin	84 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	41 NX
Pancreas	41 NX

Mucus-secreting cells	121 NX
Colon	170 NX
Rectum	117 NX
Small intestine	103 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	66 NX
Pancreas	66 NX

Paneth cells	42 NX
Rectum	97 NX
Small intestine	42 NX
Colon	29 NX

Peritubular cells	53 NX
Testis	53 NX

Proximal tubular cells	21 NX
Kidney	21 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	44 NX
Pancreas	78 NX
Skin	46 NX
Heart muscle	44 NX
Prostate	40 NX

Spermatocytes	58 NX
Testis	58 NX

Spermatogonia	100 NX
Testis	100 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	52 NX
Colon	57 NX
Kidney	53 NX
Skin	52 NX
Liver	43 NX
Prostate	31 NX
Lung	27 NX

Undifferentiated cells	96 NX
Colon	125 NX
Rectum	96 NX
Small intestine	72 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.