Cell type atlas - FAM210B - The Human Protein Atlas

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FAM210B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM210B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 210 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, Peritubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, Peritubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	21 NX
Lung	21 NX

B-cells	2 NX
Liver	6 NX
Kidney	5 NX
Colon	0 NX

Basal glandular cells	74 NX
Prostate	74 NX

Basal keratinocytes	22 NX
Skin	22 NX

Bipolar cells	8 NX
Eye	8 NX

Cardiomyocytes	53 NX
Heart muscle	53 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	1 NX
Lung	1 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	61 NX
Placenta	61 NX

Distal tubular cells	55 NX
Kidney	55 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	25 NX
Liver	43 NX
Skin	38 NX
Testis	34 NX
Heart muscle	29 NX
Eye	25 NX
Placenta	20 NX
Prostate	16 NX
Pancreas	14 NX
Lung	9 NX

Enterocytes	25 NX
Small intestine	32 NX
Rectum	30 NX
Colon	12 NX

Erythroid cells	234 NX
Liver	234 NX

Exocrine glandular cells	17 NX
Pancreas	17 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	26 NX
Heart muscle	34 NX
Lung	33 NX
Placenta	29 NX
Prostate	26 NX
Skin	20 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	20 NX
Colon	37 NX
Lung	2 NX

Hepatocytes	107 NX
Liver	107 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	49 NX
Colon	51 NX
Rectum	47 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	42 NX
Liver	42 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	62 NX
Testis	62 NX

Macrophages	18 NX
Testis	30 NX
Kidney	27 NX
Skin	21 NX
Prostate	18 NX
Lung	12 NX
Pancreas	9 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	27 NX
Rectum	40 NX
Small intestine	20 NX
Colon	16 NX

Muller glia cells	25 NX
Eye	25 NX

Pancreatic endocrine cells	33 NX
Pancreas	33 NX

Paneth cells	7 NX
Rectum	29 NX
Small intestine	7 NX
Colon	6 NX

Peritubular cells	146 NX
Testis	146 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	28 NX
Prostate	32 NX
Pancreas	28 NX
Heart muscle	28 NX
Skin	24 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	10 NX
Testis	10 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	35 NX
Placenta	35 NX

T-cells	13 NX
Skin	14 NX
Prostate	13 NX
Liver	13 NX
Kidney	13 NX
Colon	12 NX
Lung	7 NX

Undifferentiated cells	32 NX
Rectum	41 NX
Small intestine	34 NX
Colon	19 NX

Urothelial cells	45 NX
Prostate	45 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.