Cell type atlas - AGO2 - The Human Protein Atlas

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AGO2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AGO2
Gene descriptionⁱ Full gene name according to HGNC.	Argonaute 2, RISC catalytic component
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	21 NX
Lung	21 NX

B-cells	18 NX
Kidney	22 NX
Colon	22 NX
Liver	7 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	25 NX
Eye	25 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	41 NX
Eye	41 NX

Cytotrophoblasts	37 NX
Placenta	36 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	23 NX
Pancreas	23 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	25 NX
Prostate	99 NX
Pancreas	32 NX
Lung	29 NX
Liver	27 NX
Testis	25 NX
Heart muscle	20 NX
Placenta	20 NX
Eye	15 NX
Skin	14 NX

Enterocytes	10 NX
Rectum	19 NX
Small intestine	11 NX
Colon	7 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	16 NX
Pancreas	16 NX

Extravillous trophoblasts	17 NX
Placenta	17 NX

Fibroblasts	24 NX
Prostate	94 NX
Lung	43 NX
Heart muscle	34 NX
Placenta	25 NX
Skin	13 NX

Glandular cells	85 NX
Prostate	85 NX

Granulocytes	16 NX
Lung	23 NX
Colon	9 NX

Hepatocytes	12 NX
Liver	12 NX

Hofbauer cells	13 NX
Placenta	13 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	23 NX
Rectum	40 NX
Colon	7 NX

Ito cells	26 NX
Liver	26 NX

Kupffer cells	24 NX
Liver	24 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	19 NX
Prostate	69 NX
Skin	30 NX
Lung	28 NX
Testis	20 NX
Kidney	18 NX
Pancreas	0 NX

Melanocytes	5 NX
Skin	5 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	23 NX
Rectum	25 NX
Small intestine	14 NX
Colon	9 NX

Muller glia cells	31 NX
Eye	31 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	18 NX
Rectum	22 NX
Small intestine	18 NX
Colon	12 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	13 NX
Prostate	104 NX
Heart muscle	38 NX
Pancreas	13 NX
Skin	12 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	21 NX
Skin	21 NX

Syncytiotrophoblasts	66 NX
Placenta	66 NX

T-cells	25 NX
Prostate	48 NX
Colon	32 NX
Lung	26 NX
Liver	24 NX
Kidney	20 NX
Skin	19 NX

Undifferentiated cells	20 NX
Rectum	27 NX
Small intestine	20 NX
Colon	5 NX

Urothelial cells	79 NX
Prostate	79 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.