Cell type atlas - GIPC1 - The Human Protein Atlas

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GIPC1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GIPC1
Gene descriptionⁱ Full gene name according to HGNC.	GIPC PDZ domain containing family member 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	12 NX
Colon	15 NX
Kidney	9 NX
Liver	8 NX

Basal glandular cells	48 NX
Prostate	48 NX

Basal keratinocytes	101 NX
Skin	101 NX

Bipolar cells	66 NX
Eye	66 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	4 NX
Lung	4 NX

Club cells	16 NX
Lung	16 NX

Collecting duct cells	79 NX
Kidney	79 NX

Cone photoreceptor cells	33 NX
Eye	33 NX

Cytotrophoblasts	29 NX
Placenta	29 NX

Distal tubular cells	45 NX
Kidney	45 NX

Ductal cells	162 NX
Pancreas	162 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	27 NX
Placenta	67 NX
Pancreas	47 NX
Eye	34 NX
Skin	33 NX
Liver	27 NX
Prostate	22 NX
Testis	19 NX
Heart muscle	8 NX
Lung	6 NX

Enterocytes	262 NX
Colon	434 NX
Rectum	388 NX
Small intestine	30 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	147 NX
Pancreas	147 NX

Extravillous trophoblasts	56 NX
Placenta	56 NX

Fibroblasts	41 NX
Placenta	66 NX
Skin	40 NX
Prostate	21 NX
Lung	11 NX
Heart muscle	5 NX

Glandular cells	97 NX
Prostate	97 NX

Granulocytes	10 NX
Colon	18 NX
Lung	2 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	72 NX
Eye	72 NX

Intestinal endocrine cells	41 NX
Colon	48 NX
Rectum	35 NX

Ito cells	19 NX
Liver	19 NX

Kupffer cells	10 NX
Liver	10 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	19 NX
Testis	19 NX

Macrophages	14 NX
Pancreas	61 NX
Skin	25 NX
Prostate	17 NX
Kidney	11 NX
Testis	8 NX
Lung	3 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	38 NX
Pancreas	38 NX

Mucus-secreting cells	63 NX
Colon	123 NX
Rectum	73 NX
Small intestine	35 NX

Muller glia cells	61 NX
Eye	61 NX

Pancreatic endocrine cells	195 NX
Pancreas	195 NX

Paneth cells	131 NX
Colon	596 NX
Rectum	131 NX
Small intestine	28 NX

Peritubular cells	24 NX
Testis	24 NX

Proximal tubular cells	38 NX
Kidney	38 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	38 NX
Pancreas	108 NX
Prostate	41 NX
Skin	37 NX
Heart muscle	8 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	21 NX
Testis	21 NX

Suprabasal keratinocytes	148 NX
Skin	148 NX

Syncytiotrophoblasts	22 NX
Placenta	22 NX

T-cells	14 NX
Skin	29 NX
Kidney	26 NX
Colon	22 NX
Prostate	13 NX
Liver	13 NX
Lung	3 NX

Undifferentiated cells	66 NX
Colon	226 NX
Rectum	109 NX
Small intestine	37 NX

Urothelial cells	154 NX
Prostate	154 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.