Cell type atlas - ACO1 - The Human Protein Atlas

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ACO1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACO1
Gene descriptionⁱ Full gene name according to HGNC.	Aconitase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	26 NX
Lung	25 NX

B-cells	8 NX
Kidney	9 NX
Liver	7 NX
Colon	6 NX

Basal glandular cells	7 NX
Prostate	7 NX

Basal keratinocytes	4 NX
Skin	4 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	40 NX
Heart muscle	40 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	8 NX
Lung	8 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	40 NX
Placenta	40 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	14 NX
Pancreas	14 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	18 NX
Lung	47 NX
Liver	25 NX
Heart muscle	19 NX
Prostate	19 NX
Testis	16 NX
Eye	14 NX
Skin	14 NX
Placenta	12 NX
Pancreas	11 NX

Enterocytes	30 NX
Small intestine	50 NX
Rectum	30 NX
Colon	20 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	36 NX
Pancreas	36 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	22 NX
Prostate	40 NX
Heart muscle	27 NX
Skin	22 NX
Lung	21 NX
Placenta	17 NX

Glandular cells	11 NX
Prostate	11 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	175 NX
Liver	175 NX

Hofbauer cells	13 NX
Placenta	13 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	5 NX
Rectum	9 NX
Colon	0 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	7 NX
Pancreas	44 NX
Lung	36 NX
Kidney	22 NX
Prostate	5 NX
Testis	5 NX
Skin	5 NX

Melanocytes	7 NX
Skin	7 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	32 NX
Rectum	33 NX
Small intestine	29 NX
Colon	12 NX

Muller glia cells	31 NX
Eye	31 NX

Pancreatic endocrine cells	23 NX
Pancreas	23 NX

Paneth cells	21 NX
Rectum	23 NX
Small intestine	21 NX
Colon	20 NX

Peritubular cells	22 NX
Testis	22 NX

Proximal tubular cells	161 NX
Kidney	161 NX

Rod photoreceptor cells	14 NX
Eye	14 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	22 NX
Pancreas	35 NX
Prostate	26 NX
Heart muscle	22 NX
Skin	17 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	5 NX
Skin	5 NX

Syncytiotrophoblasts	45 NX
Placenta	45 NX

T-cells	9 NX
Kidney	18 NX
Liver	11 NX
Prostate	9 NX
Lung	6 NX
Colon	5 NX
Skin	5 NX

Undifferentiated cells	27 NX
Small intestine	37 NX
Rectum	27 NX
Colon	19 NX

Urothelial cells	7 NX
Prostate	7 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.