Cell type atlas - CLTA - The Human Protein Atlas

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CLTA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLTA
Gene descriptionⁱ Full gene name according to HGNC.	Clathrin light chain A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	119 NX
Lung	119 NX

Alveolar cells type 2	127 NX
Lung	127 NX

B-cells	113 NX
Colon	124 NX
Liver	108 NX
Kidney	103 NX

Basal glandular cells	237 NX
Prostate	237 NX

Basal keratinocytes	175 NX
Skin	175 NX

Bipolar cells	139 NX
Eye	139 NX

Cardiomyocytes	43 NX
Heart muscle	43 NX

Cholangiocytes	199 NX
Liver	199 NX

Ciliated cells	195 NX
Lung	195 NX

Club cells	110 NX
Lung	110 NX

Collecting duct cells	171 NX
Kidney	171 NX

Cone photoreceptor cells	57 NX
Eye	57 NX

Cytotrophoblasts	788 NX
Placenta	788 NX

Distal tubular cells	393 NX
Kidney	393 NX

Ductal cells	429 NX
Pancreas	429 NX

Early spermatids	39 NX
Testis	39 NX

Endothelial cells	222 NX
Liver	360 NX
Placenta	303 NX
Testis	288 NX
Pancreas	283 NX
Prostate	237 NX
Skin	212 NX
Eye	165 NX
Lung	128 NX
Heart muscle	68 NX

Enterocytes	317 NX
Small intestine	342 NX
Colon	285 NX
Rectum	277 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	294 NX
Pancreas	294 NX

Extravillous trophoblasts	375 NX
Placenta	375 NX

Fibroblasts	205 NX
Placenta	273 NX
Prostate	213 NX
Skin	183 NX
Heart muscle	81 NX
Lung	71 NX

Glandular cells	232 NX
Prostate	232 NX

Granulocytes	72 NX
Colon	74 NX
Lung	70 NX

Hepatocytes	147 NX
Liver	147 NX

Hofbauer cells	759 NX
Placenta	759 NX

Horizontal cells	87 NX
Eye	87 NX

Intestinal endocrine cells	176 NX
Colon	194 NX
Rectum	159 NX

Ito cells	320 NX
Liver	320 NX

Kupffer cells	351 NX
Liver	351 NX

Late spermatids	70 NX
Testis	70 NX

Leydig cells	243 NX
Testis	243 NX

Macrophages	230 NX
Pancreas	356 NX
Kidney	313 NX
Prostate	263 NX
Testis	241 NX
Lung	163 NX
Skin	152 NX

Melanocytes	186 NX
Skin	186 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	341 NX
Pancreas	341 NX

Mucus-secreting cells	270 NX
Colon	413 NX
Rectum	274 NX
Small intestine	238 NX

Muller glia cells	211 NX
Eye	211 NX

Pancreatic endocrine cells	383 NX
Pancreas	383 NX

Paneth cells	323 NX
Colon	518 NX
Small intestine	323 NX
Rectum	309 NX

Peritubular cells	203 NX
Testis	203 NX

Proximal tubular cells	508 NX
Kidney	508 NX

Rod photoreceptor cells	105 NX
Eye	105 NX

Sertoli cells	175 NX
Testis	175 NX

Smooth muscle cells	194 NX
Pancreas	399 NX
Prostate	214 NX
Skin	181 NX
Heart muscle	73 NX

Spermatocytes	246 NX
Testis	246 NX

Spermatogonia	233 NX
Testis	233 NX

Suprabasal keratinocytes	169 NX
Skin	169 NX

Syncytiotrophoblasts	1087 NX
Placenta	1087 NX

T-cells	114 NX
Kidney	147 NX
Liver	119 NX
Colon	116 NX
Skin	108 NX
Prostate	83 NX
Lung	49 NX

Undifferentiated cells	300 NX
Colon	376 NX
Small intestine	316 NX
Rectum	295 NX

Urothelial cells	287 NX
Prostate	287 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.