Cell type atlas - A1BG - The Human Protein Atlas

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A1BG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	A1BG
Gene descriptionⁱ Full gene name according to HGNC.	Alpha-1-B glycoprotein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HEK93, Hep G2, REH, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	48 NX
Liver	64 NX
Kidney	40 NX
Colon	3 NX

Basal glandular cells	2 NX
Prostate	2 NX

Basal keratinocytes	8 NX
Skin	8 NX

Bipolar cells	3 NX
Eye	3 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	1 NX
Pancreas	1 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	10 NX
Liver	45 NX
Placenta	16 NX
Eye	15 NX
Testis	14 NX
Skin	11 NX
Prostate	4 NX
Heart muscle	1 NX
Lung	0 NX
Pancreas	0 NX

Enterocytes	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	8 NX
Pancreas	8 NX

Extravillous trophoblasts	7 NX
Placenta	7 NX

Fibroblasts	28 NX
Skin	47 NX
Placenta	30 NX
Prostate	12 NX
Lung	4 NX
Heart muscle	1 NX

Glandular cells	11 NX
Prostate	11 NX

Granulocytes	16 NX
Lung	33 NX
Colon	0 NX

Hepatocytes	1228 NX
Liver	1228 NX

Hofbauer cells	26 NX
Placenta	26 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	1 NX
Rectum	2 NX
Colon	0 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	96 NX
Liver	96 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	1 NX
Testis	1 NX

Macrophages	50 NX
Skin	67 NX
Testis	55 NX
Prostate	51 NX
Kidney	50 NX
Pancreas	47 NX
Lung	21 NX

Melanocytes	110 NX
Skin	110 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	48 NX
Pancreas	48 NX

Mucus-secreting cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Muller glia cells	2 NX
Eye	2 NX

Pancreatic endocrine cells	9 NX
Pancreas	9 NX

Paneth cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	52 NX
Skin	68 NX
Pancreas	52 NX
Prostate	28 NX
Heart muscle	0 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	3 NX
Skin	3 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	35 NX
Skin	97 NX
Liver	57 NX
Prostate	35 NX
Lung	33 NX
Kidney	27 NX
Colon	5 NX

Undifferentiated cells	0 NX
Rectum	0 NX
Small intestine	0 NX
Colon	0 NX

Urothelial cells	1 NX
Prostate	1 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.