Cell type atlas - ECHDC2 - The Human Protein Atlas

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ECHDC2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ECHDC2
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA hydratase domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BEWO, HHSteC, THP-1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	72 NX
Lung	72 NX

B-cells	17 NX
Kidney	22 NX
Liver	12 NX
Colon	12 NX

Basal glandular cells	78 NX
Prostate	78 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	55 NX
Heart muscle	55 NX

Cholangiocytes	120 NX
Liver	120 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	82 NX
Kidney	82 NX

Cone photoreceptor cells	308 NX
Eye	308 NX

Cytotrophoblasts	163 NX
Placenta	163 NX

Distal tubular cells	151 NX
Kidney	151 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	111 NX
Testis	111 NX

Endothelial cells	20 NX
Liver	32 NX
Lung	32 NX
Eye	26 NX
Testis	21 NX
Prostate	20 NX
Heart muscle	16 NX
Skin	11 NX
Placenta	11 NX
Pancreas	4 NX

Enterocytes	107 NX
Small intestine	133 NX
Colon	89 NX
Rectum	81 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	52 NX
Pancreas	52 NX

Extravillous trophoblasts	12 NX
Placenta	12 NX

Fibroblasts	47 NX
Heart muscle	71 NX
Prostate	68 NX
Placenta	53 NX
Lung	46 NX
Skin	42 NX

Glandular cells	91 NX
Prostate	91 NX

Granulocytes	29 NX
Lung	30 NX
Colon	28 NX

Hepatocytes	664 NX
Liver	664 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	50 NX
Colon	51 NX
Rectum	49 NX

Ito cells	26 NX
Liver	26 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	134 NX
Testis	134 NX

Leydig cells	143 NX
Testis	143 NX

Macrophages	17 NX
Lung	38 NX
Kidney	21 NX
Prostate	20 NX
Testis	14 NX
Skin	10 NX
Pancreas	7 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	59 NX
Small intestine	102 NX
Colon	67 NX
Rectum	52 NX

Muller glia cells	58 NX
Eye	58 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	124 NX
Small intestine	130 NX
Colon	124 NX
Rectum	60 NX

Peritubular cells	106 NX
Testis	106 NX

Proximal tubular cells	258 NX
Kidney	258 NX

Rod photoreceptor cells	156 NX
Eye	156 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	47 NX
Skin	53 NX
Heart muscle	47 NX
Prostate	42 NX
Pancreas	9 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	104 NX
Placenta	104 NX

T-cells	39 NX
Lung	59 NX
Kidney	50 NX
Skin	46 NX
Prostate	39 NX
Liver	35 NX
Colon	35 NX

Undifferentiated cells	57 NX
Small intestine	66 NX
Rectum	59 NX
Colon	51 NX

Urothelial cells	68 NX
Prostate	68 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.